Diabex XR Sustained Release Tablet 500 mg (Metformin Hydrochloride)

Adult dose

The general initial dose is 500 mg of Metformin Hydrochloride sustained release tablet taken once daily with the evening meal. After one week, measure blood sugar levels to adjust the dosage. The dose can be increased weekly by 500 mg to a maximum of 2000 mg taken with the evening meal. If blood sugar control is not achieved with a maximum of 2000 mg once daily, consider a dosage of 1000 mg twice daily, both taken with meals.

This medication can rarely cause serious lactic acidosis, so caution is required. There is a risk of hypoglycemia when used with other diabetes medications, so care must be taken. This medication should not be used in patients with moderate to severe renal impairment or conditions such as dehydration, severe infections, and acute myocardial infarction. Patients with acute heart failure or those scheduled for examinations using radiographic iodine contrast agents should also not be administered this medication. It should not be administered to patients with allergies to its ingredients, type 1 diabetes, or severe metabolic acidosis. In cases of severe infections, trauma, or before and after surgery, this medication should be temporarily discontinued and resumed only when kidney function is normal. Patients with poor nutritional status, liver dysfunction, respiratory failure, or excessive alcohol consumption require caution when using this medication. Should not be initiated in pregnant women with placental insufficiency or at risk for preeclampsia. Patients with irregular meals, intense exercise, or taking interacting medications should use this medication cautiously due to the risk of hypoglycemia and lactic acidosis. This medication may cause gastrointestinal distress, vitamin B12 deficiency, taste disturbance, and other side effects; if symptoms occur, consult a healthcare professional. Regular kidney function tests are necessary to monitor renal status, and if kidney function deteriorates, administration should be discontinued. Alcohol consumption can affect lactate metabolism and increase risks, so it is advisable to avoid it. This medication may interact with other drugs, so blood sugar and conditions should be closely monitored when used in combination. If blood sugar control is needed during pregnancy, it may be used in combination with insulin at the physician's discretion, but fetal development monitoring is necessary. During breastfeeding, this medication is excreted in breast milk, so careful consideration of whether to breastfeed and whether to discontinue medication therapy is required. Elderly patients are at higher risk for decreased kidney function; treatment should start at the minimum dose and kidney function should be checked regularly. In the event of overdose, blood dialysis can remove the drug, so immediate medical attention is necessary. Do not crush or chew the tablets, and it is normal for the tablet coating to appear in the stool. During the use of this medication, adherence to dietary therapy, regular exercise, and consistent monitoring of blood sugar and kidney function tests is essential.

Serious side effects

Lactic acidosis (a rare but serious metabolic complication that can be fatal; symptoms include lethargy, myalgia, dyspnea, weakness, abdominal pain, hypothermia, hypotension, and bradyarrhythmia)

Mild side effects

• Vitamin B12 deficiency
• taste disturbance
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• pruritus
• urticaria

Store this medication in a tightly closed container to protect it from air and moisture. Additionally, it is recommended to store it at room temperature between 1°C and 30°C, away from extreme heat or cold.

Appearance

White to off-white, double-convex, round sustained release tablets

Package unit

60 tablets (15 tablets/PTP) × 4