Tasigna Tablet 100 mg (Erlotinib Hydrochloride)

Adult dose

1. Non-small cell lung cancer Take 150mg once daily at least 1 hour before a meal or at least 2 hours after a meal. Treatment with this medicine may continue until disease progression or unacceptable toxicity occurs. 2. Pancreatic cancer In combination with gemcitabine, take 100mg once daily at least 1 hour before a meal or at least 2 hours after a meal. Treatment with this medicine may continue until disease progression or unacceptable toxicity occurs. 3. Dose adjustment If a dose reduction is needed, reduce the dose by 50mg. Consider a dose reduction if severe adverse reactions occur in patients receiving concomitant potent CYP3A4 inhibitors such as atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin (TAO), voriconazole, or grapefruit juice. If the CYP3A4 inducer rifampicin is administered before this medicine, the AUC of this medicine may decrease by approximately 2/3. Therefore, consider using an alternative medicine that does not induce CYP3A4. If no alternative is available, consider administering more than 150mg for non-small cell lung cancer or more than 100mg for pancreatic cancer, while monitoring the patient's safety and confirming tolerability. If the dose of this medicine has been increased, reduce it when rifampicin or another inducer is discontinued. Smoking appears to reduce exposure to this medicine by approximately 50-60%. The maximum tolerated dose of this medicine in current smokers with non-small cell lung cancer is 300mg. In patients who continue to smoke, administration of 300mg as second-line therapy after chemotherapy did not improve efficacy compared with the recommended dose of 150mg.

This medication can cause serious side effects in the lungs. If symptoms worsening such as cough, shortness of breath, or fever appear, the medication should be stopped immediately and a doctor consulted. There is also a risk of heart problems, so caution is advised if chest pain or sudden discomfort occurs. As cerebrovascular accidents can occur, sudden headaches, dizziness, or speech difficulties require an immediate visit to the hospital. Decreased platelet counts can lead to problems with blood coagulation, raising the risk of bleeding. Diarrhea and dehydration can occur, and in severe cases, kidney function may be compromised, leading to a need for adequate hydration and consultation with medical personnel. Since this medication can affect liver function, patients with liver disease should have regular liver function tests, and discontinuation is necessary if liver function deteriorates. As gastrointestinal perforations can occur, immediate medical attention is required for symptoms such as abdominal pain, vomiting, or blood in stools. Severe rashes or blisters can occur on the skin, so if skin abnormalities appear, the medication should be stopped immediately and a doctor consulted. If there is inflammation or pain in the eyes, as well as blurred vision, immediate treatment by an ophthalmologist is necessary; caution is advised when using contact lenses. This medication cannot be used in patients with certain genetic disorders, and those with poor liver or kidney function should use it cautiously. Women who are pregnant or may become pregnant must use contraception while taking this medication, and breastfeeding women are advised to avoid it. This medication may interact with other drugs, so it is essential to inform medical personnel of any current medications being taken. Smoking can reduce the effectiveness of this medication, so it is advisable to quit smoking while taking it. In case of overdose, serious side effects like diarrhea, rash, or liver function abnormalities may occur, so it is essential to adhere to the prescribed dosage. Keep out of reach of children, and do not transfer to another container for safety.

Interstitial lung disease-like symptoms, pneumonia, radiation pneumonia, hypersensitivity pneumonia, interstitial pneumonia, obstructive bronchiolitis, pulmonary fibrosis, acute respiratory distress syndrome, lung infiltration, dyspnea, cough, fever, myocardial infarction, cerebrovascular accident, microangiopathic hemolytic anemia accompanied by thrombocytopenia, diarrhea, dehydration, electrolyte imbalance, renal failure, hepatitis, acute hepatitis, liver failure, gastrointestinal perforation, vesicular and exfoliative skin disorders, Stevens-Johnson syndrome, toxic epidermal necrolysis, corneal perforation, corneal ulcer, abnormal eyelash growth, dry conjunctivitis, keratitis, rash, loss of appetite, fatigue, nausea, infection, vomiting, stomatitis, itching, dry skin, conjunctivitis, dry conjunctivitis, abdominal pain, leukopenia, edema, fever, constipation, bone pain, myalgia, depression, dyspepsia, dizziness, headache, insomnia, alopecia, anxiety, neuropathy, distention, rigidity, deep vein thrombosis, syncope, arrhythmia, intestinal pigmentation, pancreatitis, thrombocytopenia, hemolytic anemia, cerebral hemorrhage, liver function impairment, gastrointestinal bleeding, hematemesis, melena, eyelash entrapment, excessive eyelash growth, hypertrophy, liver abscess, pulmonary embolism, sepsis, pneumonia, systemic weakness, hemoptysis, sputum, mucositis, pain, neutropenia, asthenia, anemia, hirsutism, paronychia, nail brittleness and waviness, uveitis, intestinal emphysema, elevated INR, bleeding, rhabdomyolysis, myopathy

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. Additionally, it is important to maintain a temperature between 1°C and 30°C while storing the medication. Proper storage will safely maintain the efficacy of the drug.

Appearance

White to slightly yellow round film-coated tablet

Package unit

30 tablets (10 tablets/PTP packaging x 3)