Metgreen SR Tablet 500mg (Metformin Hydrochloride)

Adult dose

The initial dose is 500mg of Metformin Hydrochloride SR tablet once daily with the evening meal. After a week, measure blood sugar levels to adjust the dosage, and dosage increases should be gradual at 500mg per week. The maximum dosage is up to 2000mg per day and can be taken with the evening meal. If blood sugar control is insufficient, 1000mg twice daily with meals should be considered.

This medication can rarely cause severe lactic acidosis which can be life-threatening, so patients should be cautious of symptoms of lactic acidosis while taking this medication. In addition, hypoglycemia may occur when taken in conjunction with insulin or sulfonylurea medications, so blood sugar levels should be closely monitored. Patients with moderate to severe renal impairment, dehydration, severe infections, or acute illnesses affecting renal function such as acute myocardial infarction should not use this medication. Patients with acute and unstable heart failure should also avoid taking this medication, and it should be discontinued for a certain period before and after examinations using iodinated contrast media. Patients who are allergic to this medication or to biguanides, patients with type 1 diabetes, and those with a history of lactic acidosis or diabetic ketoacidosis should also avoid its use. Patients with severe infections, trauma, pre- and post-surgery, malnutrition, hepatic impairment, severe respiratory failure, and those who consume excessive alcohol should also suspend or use this medication with caution. While taking this medication, gastrointestinal disorders, taste disturbances, and vitamin B12 deficiency may occur, so patients should consult a doctor if symptoms are severe. Renal function should be monitored regularly to ensure the safe use of this medication, and particular caution is needed for elderly patients or those with reduced renal function. Hypoglycemia may occur, so blood sugar levels should be carefully managed in situations of irregular meals, vigorous exercise, or in combination with other hypoglycemic agents. Alcohol consumption can increase the risk of lactic acidosis, so it is advisable not to indulge in excessive drinking while taking this medication. Patients who are pregnant or breastfeeding should consult a physician before taking this medication, as it may affect the fetus and newborn. This medication is not recommended for children, and elderly patients may need appropriate dosage adjustments based on renal function. In case of overdose, hypoglycemia is rare, but there is a risk of lactic acidosis, and immediate medical attention should be sought for appropriate treatment. This medication may interact with other drugs, so patients should inform healthcare providers of any medications they are taking, and should consult immediately if there are changes in blood sugar levels or abnormal symptoms. Finally, this medication should be swallowed whole, and it is normal for the tablet coating to be excreted, so there is no need for concern.

Serious side effects

Lactic acidosis (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, difficulty breathing or shortness of breath, asthma attack, respiratory distress with cough and fever, jaundice (yellowing of the skin or eyes), extreme fatigue, sudden and severe headache, thunderclap headache, seizure, confusion, visual disturbances, paralysis, etc.

Mild side effects

• Vitamin B12 deficiency
• taste disturbances
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• hives

This medication should be stored in a tightly closed container to prevent air and moisture from entering. Additionally, it is best to keep the medication at room temperature between 1 to 30 degrees Celsius, avoiding extremely hot or cold environments.

Appearance

White or light yellow, biconvex, rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle