Pantokei Tablets 40mg (Pantoprazole Sodium Sesquihydrate)

Adult dose

1. Antibiotic combination therapy to prevent recurrence of gastric or duodenal ulcers infected with Helicobacter pylori In general, adults should take 40 mg of pantoprazole per dose twice daily (before breakfast and the evening meal) in combination with the following antibiotics for 1 week. Swallow without chewing or crushing. (1) Take 1,000 mg of amoxicillin and 500 mg of clarithromycin per dose twice daily for 1 week, or (2) Take 500 mg of metronidazole and 500 mg of clarithromycin per dose twice daily for 1 week, or (3) Take 1,000 mg of amoxicillin and 500 mg of metronidazole per dose twice daily for 1 week. The regimens using metronidazole in (2) and (3) should be used only when regimen 1 is inappropriate. If additional treatment with pantoprazole is indicated to ensure ulcer healing, the recommended doses according to the regimens below should be considered for duodenal and gastric ulcers. When combination therapy is not required (e.g., Helicobacter pylori-negative infection), use pantoprazole monotherapy according to the regimens below. 2. Gastric ulcer and reflux esophagitis In general, adults should take 40 mg of pantoprazole orally once daily before breakfast with water, without chewing or crushing. Most cases heal within 4 weeks, although healing time may vary between patients. If healing is not complete after the initial 4 weeks, continue treatment for an additional 4 weeks. If there has been no response to other treatments, the dose may be doubled (to 80 mg of pantoprazole daily). 3. Duodenal ulcer In general, adults should take 40 mg of pantoprazole orally once daily before breakfast with water, without chewing or crushing. Most cases heal within 2 weeks, although healing time may vary between patients. If healing is not complete after the initial 2 weeks, continue treatment for an additional 2 weeks. If there has been no response to other treatments, the dose may be doubled (to 80 mg of pantoprazole daily). 4. Zollinger-Ellison syndrome and other pathological hypersecretory conditions Start with an initial dose of 80 mg of pantoprazole daily, then increase or decrease the dose according to measurements of gastric acid secretion. For doses above 80 mg, divide the daily dose into two administrations. A temporary increase to 160 mg or more is possible, but should be used only for as long as needed to achieve adequate acid control. The duration of treatment is not limited but should be adjusted according to clinical need. For patients with severe liver impairment, reduce the dose so that it does not exceed 20mg of pantoprazole once daily. Do not exceed 40 mg of pantoprazole daily in elderly patients or patients with renal impairment. Exceptionally, elderly patients may take 40 mg of this medicine per dose twice daily (before breakfast and the evening meal) for 1 week as part of the antibiotic combination therapy described above, without chewing or crushing. Do not use antibiotic combination therapy in patients with moderate to severe hepatic/renal impairment. There are insufficient data on the efficacy and safety of this combination therapy.

This medication should not be administered to patients with moderate to severe impairment of liver or kidney function. Do not use this medication if you are allergic to this drug, its components, or benzimidazole derivatives, or if you have a history of hypersensitivity. Special caution is required as serious allergic reactions such as anaphylaxis, angioedema, bronchospasm, acute interstitial nephritis, and urticaria may occur. Additionally, if there is a hypersensitivity to penicillin or macrolide antibiotics, the risk of allergic reactions when combined with antibiotics should be avoided. There may be significant interactions when used with certain heart-related medications or antivirals, so it should be avoided in combination. Pregnant women in the early stages or those who may become pregnant, and nursing mothers should avoid taking this medication. This drug can cause various side effects in the gastrointestinal, systemic, hepatobiliary, immune, musculoskeletal, nervous, mental, and skin systems. For example, abdominal pain, constipation, diarrhea, fatigue, abnormal liver function, headache, depression, skin rash may occur, and in severe cases, anaphylactic shock or serious skin conditions can arise. Long-term use may increase the risk of gastric polyps, and nutritional issues due to impaired absorption of vitamin B12 may also occur. This drug suppresses gastric acid secretion, which can increase the number of bacteria in the stomach, thereby slightly increasing the risk of infection. Dizziness or vision disturbances may occur during use, so care is needed when driving or operating machinery. Due to many interactions with other drugs, it is essential to consult a doctor or pharmacist before or during the use of this medication. In particular, when using in conjunction with anticoagulants, antivirals, certain antibiotics, or immunosuppressants, blood tests or symptom observation may be necessary. During pregnancy or nursing, this drug can potentially affect the fetus or infant, so it should be avoided unless necessary and discussed with a specialist. The safety and efficacy of this medication in children and adolescents have not been sufficiently confirmed, so its use is not recommended. No specific symptoms have been reported in cases of overdose, but if abnormal symptoms occur, a medical institution should be visited immediately for appropriate treatment. This medication should be swallowed whole without chewing or crushing and kept out of reach of children. It is also important to maintain the quality of the drug by not transferring it to another container. If this medication is taken for a long time, regular check-ups by a physician and using the lowest effective dose for the necessary duration is advisable.

• Upper abdominal pain
• constipation
• bloating
• diarrhea
• nausea
• vomiting
• belching
• dry mouth
• fatigue
• asthenia

This medication should be stored in a tightly closed container that can block light, and the storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature. This storage method preserves the effectiveness of the medication and prevents deterioration.

Appearance

Bright yellow, elliptical, film-coated tablets with a convex shape on both sides

Package unit

30 tablets/bottle, 100 tablets/bottle