Itraconazole Tablets (Itraconazole Solid Dispersion)

Adult dosage

This product continues to exert a therapeutic effect in skin tissue even after discontinuation. Therefore, it is preferable to assess the final clinical and mycological therapeutic effects 2～4 weeks after completing the prescribed treatment. 1. Short-term treatment 1) Candidal vaginitis: Administer itraconazole 200 mg per dose, 2 times daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Pityriasis versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris: Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital), tinea pedis (interdigital): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palmar), tinea pedis (plantar): Administer 100 mg once daily for 30 days or 200 mg per dose, 2 times daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg per dose, 2 times daily for 1 week, followed by a 3-week treatment-free interval; this constitutes 1 cycle. Administer up to 2 cycles if only the fingernails are infected, and up to 3 cycles if the toenails are infected. Site of onychomycosis Week 1 / Week 2 / Week 3 / Week 4 / Week 5 / Week 6 / Week 7 / Week 8 / Week 9 Toenails (with or without fingernail infection): Treatment / No treatment / Treatment / No treatment / Treatment Fingernails: Treatment / No treatment / Treatment Or 2) Continuous therapy Administer 200 mg once daily for 3 months. After treatment ends, the therapeutic effect continues for 3 months for fingernails and 6 months for toenails. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplants, the oral bioavailability of this product may be reduced; therefore, the dose may be doubled if necessary. Aspergillosis: 200mg once daily, 2～5 months. For invasive or disseminated disease, increase to 200mg per dose, 2 times daily. Candidiasis: 100～200mg once daily, 3 weeks～7 months. Cryptococcal meningitis: 200mg 2 times daily, 2 months～1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily, 6 months.

This medication should not be used in patients with compromised cardiac function, especially those with congestive heart failure. If symptoms of heart failure appear, treatment should be stopped immediately. Additionally, it should not be administered to patients allergic to this drug or its components, pregnant women or women who may become pregnant, and nursing mothers. This drug is primarily metabolized in the liver, so it should be used with caution in patients with impaired liver function, requiring regular liver function tests. Caution should also be exercised with patients having renal impairment or weakened immune systems, as dose adjustments may be necessary. There are many drug interactions with this medication, so consultation with a physician or pharmacist is essential, especially when taken with cardiac medications, antibiotics, anticancer agents, antipsychotics, etc. Gastrointestinal symptoms such as headache, nausea, abdominal pain, diarrhea, or skin reactions such as rash and itching may occur; report any unusual symptoms. Rarely, severe liver damage, cardiac arrhythmias, or hearing loss may occur, requiring careful monitoring. Caution is required for dizziness, visual impairment, or hearing loss during driving or operating machinery. In case of overdose, there is no specific antidote, and immediate medical attention should be sought for appropriate treatment. Lastly, this medication should be kept out of the reach of children and stored in its original container to maintain quality.

• Headache
• nausea
• abdominal pain
• rhinitis
• sinusitis
• upper respiratory tract infection
• leukopenia
• hypersensitivity
• taste disorder
• sensory decrease

This medication should be stored in a tightly sealed container to prevent air or moisture intrusion. It is best to maintain a storage temperature between 1 and 30 degrees Celsius. Storing it this way helps preserve the drug's effectiveness for a longer period.

Appearance

White or off-white round film-coated tablets

Package unit

28 tablets/bottle, 100 tablets/bottle