Escazol Tablet (Itraconazole Solid Dispersion)

Adult dose

(Tablets)(Capsules) It is preferable to administer immediately after meals. Vulvovaginal candidiasis: Administer 200 mg of itraconazole per dose, 2 times daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. Tinea versicolor: Administer 200 mg once daily for 7 days. Tinea corporis, tinea cruris: Administer 100 mg once daily for 15 days. Tinea manuum (interdigital), tinea pedis (interdigital): Administer 100 mg once daily for 15 days. Tinea manuum (palmar), tinea pedis (plantar): Administer 100 mg once daily for 30 days or 200 mg per dose, 2 times daily for 7 days. Oropharyngeal candidiasis: Administer 100 mg once daily for 15 days. Fungal keratitis: Administer 200 mg once daily for 21 days. Onychomycosis, pulse therapy: Administer 200 mg per dose, 2 times daily for 1 week, followed by a 3-week drug-free period; this constitutes 1 cycle. Administer up to 2 cycles for fingernail infection only and up to 3 cycles for toenail infection. Onychomycosis, continuous therapy: Administer 200 mg once daily for 3 months. Systemic fungal infections: In patients with impaired immune function, double the dose if necessary. Aspergillosis: 200mg once daily for 2～5 months. For invasive or disseminated disease, increase to 200mg per dose, 2 times daily. Candidiasis: 100～200mg once daily for 3 weeks～7 months. Cryptococcal meningitis: 200mg 2 times daily for 2 months～1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily for 6 months. (Oral solution) Do not administer with food. Hold this drug in the mouth for about 20 seconds so that it contacts the entire oral cavity, then swallow. After swallowing, do not rinse the mouth so that the drug remains in the mouth for a longer time. Oral or esophageal candidiasis: Take 200 mg (20 mL) daily in 1～2 divided doses for 1 week. If there is no effect after 1 week, continue taking it for another 1 week. Oral or esophageal candidiasis resistant to fluconazole: Take 200～400 mg (20～40 mL) daily in 1～2 divided doses for 2 weeks. If there is no effect after 2 weeks, continue taking it for another 2 weeks. Do not use more than 400 mg daily for more than 14 days, even if symptoms do not improve.

Child dose

Prevention of fungal infections: Administer 5 mg per kg of body weight per day in 2 divided doses.

This medication can be life-threatening for patients with impaired heart function or a history of heart failure, so it should not be used unless for serious infections. If signs of heart failure occur during treatment, administration should be discontinued immediately. It should not be used in patients with hypersensitivity to this drug or those taking certain cardiac-related medications. Pregnant women, those who may become pregnant, and nursing mothers should not take this medication. Patients with reduced liver or kidney function should be monitored closely and the dosage adjusted, as their metabolism and excretion of this drug may be affected. Cautious administration is necessary for immunocompromised patients or those with specific neuropathies. Due to numerous drug interactions, the risk of side effects may increase based on concomitant drugs, so consultation with healthcare professionals is mandatory. During treatment, regular liver function tests should be conducted to check for hepatotoxicity, and any abnormal symptoms should be reported quickly. Symptoms such as dizziness, vision disturbances, and hearing loss may occur, necessitating caution when driving or operating machinery. In case of overdose, there is no specific antidote, and appropriate treatment should be applied based on symptoms, while keeping it out of the reach of children.

Decreased cardiac contractility, heart failure, headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory tract infection, leukopenia, hypersensitivity, taste disturbance, sensory reduction, sensory abnormality, tinnitus, constipation, diarrhea, dyspepsia, flatulence, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorders, edema, granulocytopenia, thrombocytopenia, anaphylactoid reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion, peripheral neuropathy, dizziness, drowsiness, tremor, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, dysphonia, cough, gastrointestinal disorders, liver failure, hepatitis, jaundice, erythematous rash, sweating, myalgia, arthralgia, renal impairment, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, increased alanine aminotransferase, increased aspartate aminotransferase, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased serum urea, increased gamma-glutamyl transferase, elevated liver enzymes, abnormal urinalysis, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, vasculogenic edema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, hearing loss, ventricular extrasystoles, atrial block, palpitations, increased bowel motility, belching, glossitis, stomatitis, abdominal flank pain, pancreatitis, increased serum total protein, increased total bilirubin, elevated LAP, loss of appetite, feelings of weakness, brown urine, skin and mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Rielle syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, elevated BUN, positive urine protein response, positive urine glucose response, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, elevated serum triglycerides, flushing, elevated serum uric acid, elevated serum potassium, serum sickness, vasculogenic edema, anaphylactic reaction, hypertriglyceridemia, tremor, blurred vision, congestive heart failure, dyspnea, severe hepatotoxicity, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, increased serum creatine phosphokinase

This medication should be stored in a sealed container to prevent air ingress, at room temperature between 1°C and 30°C. Proper storage ensures the medication's effectiveness is maintained safely.

Appearance

White or slightly yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle