Itaconazole Tablets (Itaconazole Solid Dispersion)

Adult dose

(Tablets) (Capsules) It is preferable to administer immediately after a meal. Vulvovaginal candidiasis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. Pityriasis versicolor: Administer 200 mg once daily for 7 days. Tinea corporis and tinea cruris: Administer 100 mg once daily for 15 days. Tinea manuum (interdigital type) and tinea pedis (interdigital type): Administer 100 mg once daily for 15 days. Tinea manuum (palmar) and tinea pedis (plantar): Administer 100 mg once daily for 30 days or 200 mg twice daily for 7 days. Oral candidiasis: Administer 100 mg once daily for 15 days. Fungal keratitis: Administer 200 mg once daily for 21 days. Onychomycosis Pulse therapy: Administer 200 mg twice daily for 1 week, followed by a 3-week drug-free period; this constitutes one cycle. Administer up to 2 cycles for infection of the fingernails only and up to 3 cycles for infection of the toenails. Continuous therapy: Administer 200 mg once daily for 3 months. Systemic fungal infections In patients with impaired immune function, the dose may be doubled if necessary. Aspergillosis: 200mg once daily for 2～5 months. For invasive or disseminated disease, increase the dose to 200mg twice daily. Candidiasis: 100～200mg once daily for 3 weeks～7 months. Cryptococcal meningitis: 200mg twice daily for 2 months～1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily for 6 months. (Oral solution) Do not administer with food. Keep this medicine in the mouth for approximately 20 seconds so that it contacts the entire oral cavity, then swallow. After swallowing, do not rinse the mouth so that the medicine remains in the mouth for a prolonged period. Oral and esophageal candidiasis: Take 200 mg (20 mL) daily in 1～2 divided doses for 1 week. If there is no effect after 1 week, continue for 1 more week. Fluconazole-resistant oral and esophageal candidiasis: Take 200～400 mg (20～40 mL) daily in 1～2 divided doses for 2 weeks. If there is no effect after 2 weeks, continue for 2 more weeks. Even if symptoms do not improve, do not use 400 mg daily for more than 14 days.

Child dose

Prevention of fungal infections: Administer 5 mg/kg body weight daily in 2 divided doses.

This drug should not be used in patients with weak heart function, especially those with congestive heart failure, and must be discontinued immediately if symptoms of heart failure appear. Patients with allergic reactions or hypersensitivity to this drug should not take it. Due to strong interactions with several medications, especially specific heart drugs, analgesics, antibiotics, and anticoagulants, it should not be taken together. Women who are pregnant or may become pregnant, and nursing mothers should not take this drug. Patients with hereditary metabolic issues such as lactose intolerance should also avoid this drug. Patients with poor liver function should undergo regular liver function tests when taking this drug due to the risk of liver damage. Patients with decreased kidney function may need dose adjustments, and those with weakened immune systems should consult with a physician before use. While taking this drug, symptoms such as headache, nausea, abdominal pain, etc., may occur, and rarely serious allergic reactions, hepatotoxicity, or heart problems may develop. Always consult with an expert when combining this drug with others, and if unusual symptoms occur, discontinue use and inform a healthcare provider. Additionally, caution is required when driving or operating machinery, as dizziness or vision problems may occur. This drug should also be used cautiously in children and the elderly, and in cases of overdose, symptomatic treatment is implemented. When storing, keep it out of reach of children and store it in the original container.

headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory infection, leukopenia, hypersensitivity, taste disorder, sensory decline, sensory abnormality, tinnitus, constipation, diarrhea, indigestion, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual irregularities, edema, granulocytopenia, thrombocytopenia, anaphylactoid reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion, peripheral neuropathy, dizziness, drowsiness, tremors, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, voice disorder, cough, gastrointestinal disorder, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, renal impairment, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, increased alanine aminotransferase, increased aspartate aminotransferase, increased serum alkaline phosphatase, increased blood lactate dehydrogenase, increased blood urea, increased gamma-glutamyl transferase, elevated liver enzymes, abnormal urinalysis, increased white blood cell count, increased eosinophils, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, hearing loss, ventricular premature contraction, atrial block, palpitations, increased intestinal motility, belching, glossitis, stomatitis, abdominal flank pain, pancreatitis, elevated serum total protein, increased total bilirubin, increased LAP, loss of appetite, malaise, brown urine, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, elevated BUN, positive urinary protein, positive glycosuria, decreased libido, sedation, shoulder stiffness, insomnia, thoracic pain, elevated serum triglycerides, burning sensation, elevated serum uric acid, elevated serum potassium, serum sickness, angioedema, anaphylactic reaction, hypertriglyceridemia, tremors, visual impairment, hearing loss, congestive heart failure, dyspnea, pancreatitis, significant hepatotoxicity, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, increased serum creatine phosphokinase

This drug should be stored in a sealed container to prevent exposure to air or moisture, ideally at room temperature between 1 degree and 30 degrees Celsius. This will help maintain the drug's effectiveness over time.

Appearance

White or pale yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle