Clopijen Tablets (Clopidogrel Bisulfate)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, Clopidogrel 75 mg should be administered orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start with Clopidogrel 300 mg orally once on the day of initiation as a loading dose, followed by 75 mg once daily as a maintenance dose. At this time, aspirin 75 ～

This medication prevents platelets from aggregating, helping the blood to flow more freely. This drug must be activated in the liver by a specific enzyme (CYP2C19) to be effective, and individuals with genetically reduced enzyme function may find the effectiveness of the medication diminished and require special caution. During treatment, there may be an increased risk of bleeding, which means that bleeding may take longer to stop than usual. If bleeding occurs or worsens, or if it persists for a long time, consult a doctor immediately. It should not be administered to patients with bleeding tendencies, significant liver or kidney damage, nursing mothers, or patients with certain genetic disorders such as lactose intolerance. Patients who are about to undergo surgery or invasive procedures should stop taking this medication 5 to 7 days before the procedure, and caution is particularly important when taking it with other drugs that increase bleeding risk. This medication may increase the risk of bleeding when taken with other drugs that affect blood coagulation, especially aspirin, warfarin, non-steroidal anti-inflammatory drugs, and selective serotonin reuptake inhibitors (SSRIs), so consult a doctor. Rarely, this medication might cause a serious side effect of a rapid decrease in the number of white blood cells in the blood, so if there are symptoms of fever or infection, visit a hospital immediately. Additionally, if allergic reactions such as skin rash, itching, or difficulty breathing occur, discontinue the medication immediately and consult a physician. The impact on the fetus during pregnancy is unclear, but in emergency situations such as myocardial infarction or stroke, treatment should not be delayed, and it is recommended to stop medication before delivery to reduce the risk of bleeding. For nursing mothers, it is important to carefully decide whether to continue breastfeeding or discontinue the medication, as this drug may be excreted in breast milk. The safety and effectiveness in children have not been established, and caution is necessary in elderly patients or those with impaired kidney or liver function, as the risk of bleeding may be higher, requiring dosage adjustments and careful monitoring. In the case of overdose, the risk of bleeding significantly increases, and since there is no specific antidote, treatment for bleeding may require platelet transfusions or similar interventions. This medication should be stored out of reach of children, and transferring it to another container may affect its quality.

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash with fever, blistering, peeling skin, pain in oral and ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• edema
• hypertension
• headache
• dizziness
• abdominal pain

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, and it is safest to keep it at room temperature between 1 degree and 30 degrees Celsius.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle