Pretot Tablets (Clopidogrel Sulfate)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel at an oral dose of 75 mg once daily. 2. For patients with acute coronary syndrome, initiate treatment on the first day with a loading dose of 300 mg taken orally once daily, and thereafter maintain with an oral dose of 75 mg once daily. Aspirin 75-325 mg should be co-administered once daily. 3. For patients with atrial fibrillation, an oral dose of 75 mg should be administered once daily.

This medication prevents blood platelets from clumping together, thereby preventing thrombosis. Individuals with genetically reduced function of a specific enzyme (CYP2C19) may have diminished efficacy with this medication, and should consult a physician to adjust treatment methods in such cases. This medication should not be taken with drugs that activate specific enzymes, as this may increase plasma drug concentrations and elevate bleeding risks; thus, co-administration with such drugs is not recommended. Patients allergic to this drug or its components, those with active bleeding, patients with severe liver damage, and breastfeeding women should not take this medication. Additionally, patients with genetic issues related to lactose should also avoid this medication. During treatment, there is a risk of bleeding; therefore, if bleeding symptoms occur, patients should immediately inform their physician. Patients at high risk for bleeding or those scheduled for surgery should consult with their physician regarding medication adjustment. Caution is advised when taking this medication with other bleeding risk drugs (e.g., warfarin, aspirin, non-steroidal anti-inflammatory drugs, selective serotonin reuptake inhibitors), as this may increase bleeding risk. While taking this medication, gastrointestinal bleeding, skin rash, headache, dizziness, diarrhea, nausea, rash, pruritus, purpura/bruising, epistaxis, fatigue, myalgia, arthralgia, back pain, dyspnea, rhinitis, cough, depression, anxiety, insomnia, weight gain, weight loss, facial flushing, appetite loss, memory issues, abnormal thinking, trembling, voice disorders, abnormal gait, hyperactivity, ataxia, hiccuping, dysphagia, glossopathy, rigidity, visual disturbances, dry eyes, transient blindness, and congestion may occur, so it is important to consult a physician if any adverse symptoms arise. Pregnant or breastfeeding women should consult a physician before taking this medication, as it may affect the fetus or infant. Elderly individuals or patients with impaired kidney or liver function may have an increased risk of bleeding, thus should use caution when taking this medication. In case of overdose, bleeding may worsen; therefore, it is vital to adhere to the prescribed dosage, and if bleeding does not stop, medical attention should be sought immediately. This medication should be stored out of reach of children and should not be transferred to other containers.

Serious side effects

Hives, angioedema, bleeding (gastrointestinal bleeding, intracranial bleeding, ocular bleeding, hematuria, hemoptysis, hematoma), severe allergic reactions, hemorrhagic stroke, thrombocytopenia, agranulocytosis, aplastic anemia, acquired hemophilia, thrombocytopenic purpura, severe edema, jaundice, hepatitis, acute liver failure, severe skin reactions (bullous dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anterior

Mild side effects

• Headache
• dizziness
• abdominal pain
• dyspepsia
• diarrhea
• nausea
• rash
• pruritus
• purpura/bruising
• epistaxis

This medication may be sensitive to air or moisture; therefore, it should be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 degree Celsius and 30 degrees Celsius. This will help to preserve the medication's effectiveness over time.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle