Il-Yang Famcyclovir Tablet 250 mg (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer 250 mg of famciclovir orally per dose 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer 250 mg of this drug orally per dose 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer 125 mg of this drug orally per dose twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this drug orally per dose twice daily. Interrupt treatment periodically every 6～12 months to observe whether the natural course of the disease has changed. 5. Patients with renal impairment: Since creatinine clearance of this drug is reduced in patients with renal impairment, dosage adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance may be calculated using the following formulas. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into consideration. A 4-hour hemodialysis session reduces the plasma concentration of this drug by approximately 75%; therefore, administer this drug immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dosage adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be used in certain patients. Patients who have had allergic reactions to this medication or its ingredients should not take it. Additionally, it contains lactose, so patients with lactose intolerance or related genetic disorders should not take it. Patients with kidney function issues should use this medication cautiously and may require dosage adjustments. This medication may cause side effects such as headaches, nausea, vomiting, dizziness, and skin rash. Particularly in elderly patients, central nervous system symptoms such as drowsiness or confusion may occur more frequently, so caution is advised. Liver function abnormalities or rare symptoms of jaundice may occur, thus monitoring liver health is important. This medication does not completely cure genital herpes, and it is advisable to avoid sexual contact when symptoms persist during treatment. Moreover, treatment should be initiated immediately upon the first sign of recurrence symptoms. Care should be taken when driving or operating machinery if dizziness or drowsiness occurs. Patients with mild to moderate liver dysfunction do not require specific dosage adjustments, but efficacy may decrease in patients with severe liver disease. This medication has a low potential for drug interactions, but specific medications may alter blood concentration or risk toxicity, so medical consultation is necessary. Women who are pregnant or breastfeeding should use this medication cautiously, and women who could become pregnant should take it only if necessary. Children under 18 years of age are not recommended to use this medication, as its safety and efficacy have not been established. Elderly patients may require dosage adjustments based on kidney function status. In cases of overdose, appropriate treatment is necessary, and dialysis can be used to reduce drug concentration. This medication should be stored in a dried place below 30 degrees Celsius and kept out of reach of children. Also, transferring it to another container is not recommended for quality maintenance.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. Storing it in a cool and dry place below 30 degrees Celsius is preferable.

Appearance

White elongated film-coated tablet

Package unit

21 tablets/bottle