Famciclovir Tablet (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg orally per dose 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of an initial episode of genital herpes Adults: Administer 250 mg of this medicine orally per dose 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of an acute recurrent episode of genital herpes Adults: Administer 125 mg of this medicine orally per dose 2 times daily for 5 days. It is preferable to start treatment during the prodromal phase or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this medicine orally per dose 2 times daily. Temporarily discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Since creatinine clearance of this medicine is reduced in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and an initial episode of genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose 2 times daily 10～29 250 mg per dose once daily 2) Treatment of an acute recurrent episode of genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59 125 mg per dose 2 times daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose 2 times daily 10～29 125 mg per dose 2 times daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following equations. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, it is preferable to administer this medicine every 48 hours, taking the dialysis interval into consideration. Since 4 hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is required for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no specific recommended dose has been established.

This medication should not be used by patients who are allergic to this drug or its components, or who have a genetic disorder that prevents lactose digestion. Patients with impaired kidney function should use this medication with caution. Common side effects such as headaches or nausea may occur, along with a variety of adverse reactions reported in different areas, including the blood, neuropsychiatric system, heart, digestive system, liver, skin, and kidneys. This drug does not completely cure genital herpes, so it is important to avoid sexual contact and maintain safe sexual relations if symptoms are present during treatment. If symptoms such as dizziness or drowsiness occur during use, driving or operating machinery should be avoided. Patients with slightly reduced liver function do not require special dosage adjustments, but there may be reduced efficacy in patients with severe liver impairment. This drug has relatively few drug interactions, but caution is needed when used in conjunction with certain medications, especially those affecting renal excretion, and toxic risks should be monitored when taken together. Women who are pregnant or breastfeeding should carefully consider the risks and benefits of using this medication, as should women who may become pregnant. Children under 18 years of age should generally avoid using this medication as its safety and efficacy have not been established. Elderly patients generally do not require dosage adjustments, but dosage may need to be adjusted if renal function is poor. In case of overdose, appropriate treatment is necessary, and blood dialysis can reduce the drug concentration in the blood. This medication should be stored in a dry place below 30 degrees Celsius, out of reach of children, and should not be transferred to another container.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. It is recommended to keep it in a cool, dry place, at a temperature below 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

21 tablets (7 tablets/PTPX3)