Metformin Tablet 500mg (Metformin Hydrochloride)

Adult dosage

Dosing should be determined based on individual response to the medication and tolerance, without exceeding the maximum daily dose. Begin with a low dose, administering 500mg two to three times a day with meals. The dose may be gradually increased weekly by 500mg, up to a maximum of 2000mg, divided into two doses taken in the morning and evening. If the dose exceeds 2000mg, it should be divided into three doses taken with meals, up to a maximum of 2550mg.

Children's dosage

Children and adolescents over 10 years of age should take 500mg once daily during or after a meal. After one week, blood sugar levels should be measured to adjust the dosage, gradually increasing the dose.

This medication can cause severe lactic acidosis or hypoglycemia, and therefore should be used with caution. It should especially not be administered to patients with moderate to severe renal impairment, dehydration, serious infections, or cardiovascular issues. Moreover, use should be discontinued in cases of acute heart failure or before and after procedures using radiologic contrast media containing iodine until renal function is confirmed normal. This medication is contraindicated in patients with hypersensitivity to it, as well as in those with type 1 diabetes or diabetic ketoacidosis. In cases of severe infections, trauma, or surgery, treatment should be paused for a certain period, and can be resumed only after renal function has been confirmed normal. Caution is also advised for patients with malnutrition, liver dysfunction, severe lung dysfunction, or excessive alcohol consumption. Hypoglycemia or lactic acidosis may occur due to irregular eating, intense exercise, or interactions with other medications during treatment. While lactic acidosis is rare, it is very dangerous, and if symptoms such as fatigue, muscle pain, respiratory distress, or abdominal pain appear, immediate medical attention should be sought. Gastrointestinal symptoms like diarrhea, nausea, and vomiting may commonly occur during initial treatment but are often temporary, alleviated by taking the medication with meals or adjusting the dose. As this medication is excreted through the kidneys, regular monitoring of renal function is necessary, and treatment should be discontinued if significant renal impairment occurs. Alcohol may increase the risk of side effects associated with this medication, so excessive drinking should be avoided during treatment. Additionally, vitamin B12 deficiency may occur, so regular blood tests are recommended. During pregnancy, it can cross the placenta and may affect fetal growth, thus requiring special caution for pregnant women, and its use is not recommended while breastfeeding. Elderly patients are at higher risk for decreased renal function, necessitating careful dose adjustment and regular renal function tests. In case of overdose, blood dialysis may be necessary, thus caution is warranted. Regular blood sugar and renal function tests, along with immediate consultation with medical personnel in case of any adverse symptoms, are important during treatment with this medication.

Serious side effects

Lactic acidosis, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin reactions (severe rash with fever, blistering, skin peeling, mucous membrane pain in mouth/eyes), respiratory issues (shortness of breath or difficulty breathing, asthma attacks, cough with fever), liver problems (yellowing of the skin or eyes, systemic fatigue), severe neurological symptoms (sudden onset

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, hypoglycemia

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius. This helps preserve the efficacy of the medication and prevents degradation.

Appearance

[Domestic] White round film-coated tablet [Export] White round film-coated tablets

Package unit

Domestic - 100 tablets/bottle, Domestic - 500 tablets/bottle, Export - 10 tablets/pouch, Export - 10 pouches/box