Pantazol Tablets (Pantoprazole Sodium Sesquihydrate)

Adult dose

1. Combination antibiotic therapy to prevent recurrence of gastroduodenal ulcers associated with Helicobacter pylori infection - In general, adults take pantoprazole 40 mg per dose 2 times daily (before breakfast and dinner) for 1 week in combination with the following antibiotics. Swallow without chewing or crushing. (1) Take amoxicillin 1,000 mg per dose and clarithromycin 500 mg per dose 2 times daily for 1 week, or (2) Take metronidazole 500 mg per dose and clarithromycin 500 mg per dose 2 times daily for 1 week, or (3) Take amoxicillin 1,000 mg per dose and metronidazole 500 mg per dose 2 times daily for 1 week. - The regimens using metronidazole in (2) and (3) should be used only when regimen 1 is inappropriate. - If additional treatment with pantoprazole is indicated to ensure ulcer healing, the dose recommendations according to the regimens below should be considered for duodenal and gastric ulcers. - If combination therapy is not required (e.g., Helicobacter pylori-negative), use pantoprazole monotherapy according to the regimens below. 2. Gastric ulcer and reflux esophagitis - In general, adults take pantoprazole 40 mg orally once daily with water before breakfast, without chewing or crushing. - Most cases may heal within 4 weeks, although healing time may vary from patient to patient. If healing is not complete after the first 4 weeks, continue treatment for another 4 weeks. - If there has been no response to other treatments in particular, the dose may be doubled (pantoprazole 80 mg per day). 3. Duodenal ulcer - In general, adults take pantoprazole 40 mg orally once daily with water before breakfast, without chewing or crushing. - Most cases may heal within 2 weeks, although healing time may vary from patient to patient. If healing is not complete after the first 2 weeks, continue treatment for another 2 weeks. - If there has been no response to other treatments in particular, the dose may be doubled (pantoprazole 80 mg per day). 4. Zollinger-Ellison syndrome and other pathological hypersecretory conditions - Start with an initial dose of pantoprazole 80 mg per day, then increase or decrease the dose according to measurements of gastric acid secretion. - Doses of 80 mg or more should be divided into 2 doses per day. - The dose may temporarily be increased to 160 mg or more, but only to the extent necessary to control acid secretion. - Treatment duration is not limited, but should be adjusted according to clinical need. ○ For patients with severe hepatic impairment, reduce the dose so that pantoprazole does not exceed 20mg once daily. ○ For older adults or patients with renal impairment, pantoprazole should not exceed 40 mg per day. As an exception, older adults may take 40 mg of this medicine per dose 2 times daily (before breakfast and dinner), without chewing or crushing, for 1 week as part of the antibiotic combination therapy described above. ○ Do not use combination antibiotic therapy in patients with moderate ∼ severe hepatic or renal impairment. There are insufficient data on the efficacy and safety of this combination therapy.

This drug should not be administered to patients with moderate or severe impairment of liver or kidney function as there is insufficient clinical experience regarding safety and efficacy. Patients with allergies to this drug, its components, or benzimidazole class drugs should exercise caution as serious allergic reactions may occur. Patients allergic to penicillin or macrolide antibiotics may be at risk when using this drug in combination, so such use should be avoided. It is safest for women in early pregnancy or those who may become pregnant, as well as nursing mothers, to avoid this medication. When using this drug long-term, regular monitoring of liver function and other health conditions is necessary. This drug may increase the risk of bacterial overgrowth in the gastrointestinal tract due to its action of suppressing gastric acid secretion, which may elevate the risk of diarrhea or gastrointestinal infections. Dizziness or visual disturbances may occur, so caution should be exercised when driving or operating machinery. This drug may interact with other medications, so expert consultation is essential, especially when taken with antiviral drugs, anticoagulants, and certain antibiotics. This medication should be taken whole and not chewed or crushed, and it is important to keep it out of the reach of children. No specific symptoms have been reported in cases of overdose, but if any abnormal symptoms appear, immediate medical attention is required.

• Upper abdominal pain
• constipation
• abdominal distension
• diarrhea
• nausea
• vomiting
• belching
• dry mouth
• fatigue
• asthenia

This drug is sensitive to light and should be stored in a tightly closed container that is light-resistant. The storage temperature should maintain room temperature between 1 and 30 degrees Celsius, and it is advisable to avoid excessively hot or cold environments.

Appearance

Yellow enteric-coated oval tablets

Package unit

30 tablets/bottle