Famvir 250 mg Tablets (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg per dose orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer this medicine 250 mg per dose orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer this medicine 125 mg per dose orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this medicine 250 mg per dose orally twice daily. Periodically discontinue treatment every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Since creatinine clearance of this medicine is decreased in patients with renal impairment, dose adjustment should be undertaken with care. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose, twice daily 10～29 250 mg per dose, once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 125 mg per dose, twice daily 10～29 125 mg per dose, once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose, twice daily 10～29 125 mg per dose, twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formulas. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis It is preferable to administer the medicine every 48 hours, taking the dialysis interval into account. Since 4 hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%, administer it immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is required in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication should not be used in patients who have had an allergic reaction to this medication or any of its components. Additionally, this medication contains lactose and should not be administered to patients with a hereditary condition that prevents proper digestion of lactose. Special caution is necessary when using this medication in patients with kidney function problems, and dose adjustments may be required. Mild symptoms such as headaches or nausea may occur during treatment, but these are generally not severe. There have been rare reports of problems such as decreased blood cell counts, so if any unusual symptoms appear, consult a healthcare professional. Neuropsychiatric symptoms such as dizziness, drowsiness, and confusion may occur, so it is advisable to avoid driving or operating machinery if these symptoms are present. Side effects such as liver dysfunction, skin rash, and itching have also been reported, so if any abnormalities occur, immediate consultation is necessary. This medication does not completely cure genital herpes, so it is important to avoid sexual contact during symptom episodes and maintain safe sexual practices. Interactions may occur when used with other medications, so be sure to inform your healthcare provider of any other medications you are taking. Women who are pregnant or breastfeeding should use this medication with caution and consult their doctor if necessary before making a decision. It is recommended not to use this medication in children under 18 years of age, as its safety and efficacy have not been established. In case of overdose, immediately visit a medical institution for appropriate treatment, and blood dialysis may be helpful. Store this medication in a dry place below 30 degrees Celsius and keep it out of reach of children.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is also recommended to keep it in a cool, dry place below 25 degrees Celsius.

Appearance

White round film-coated tablets

Package unit

21 tablets/PTP [7 tablets/PTP packaging x 3]