Prezol-Elgi (Aiac)

Adult administration

Prepare a bicarbonate-type dialysis solution in the ratio of this solution 1 : Prezol (B) 1.225 : purified water 32.775. Use 5L at a time, and dialyze over an average duration of 4 to 6 hours. The duration of dialysis, frequency, and perfusion volume should be adjusted based on the patient's condition and the type of artificial kidney machine used.

This medication should not be administered to patients with very low blood pressure or rapid heart rate. Patients with pulmonary edema or significant abnormalities in the electrocardiogram should also avoid using this medication. Patients with elevated blood potassium levels and those with blood coagulation problems should refrain from using this medication. Care must be taken when administering to patients with severe liver disease or significant diabetes-related metabolic disorders, as improper metabolism of acetic acid can lead to the manifestation of hypotensive symptoms. Patients taking digitalis preparations need to be careful as low serum potassium levels can increase the risk of digitalis toxicity. This medication can cause hypoglycemia or hyperglycemia during or after dialysis, which necessitates immediate treatment in case of blood sugar changes. Due to thirst, excessive fluid intake may lead to increases in weight and blood pressure, so proper fluid management is important. Hypocalcemia may occur during dialysis, leading to cramps or discomfort, requiring high-calcium dialysate or calcium supplements. Bone disorders such as osteoporosis or osteomalacia may arise, potentially necessitating treatment with Vitamin D3 preparations. If blood phosphorus levels are not managed, ectopic calcification may occur, requiring interventions such as phosphate-binding agents. If symptoms of dialysis disequilibrium syndrome occur (headache, nausea, vomiting, convulsions, etc.), the intensity of dialysis should be adjusted. Cardiovascular problems may lead to sudden hypotension or shock, warranting the cessation of dialysis or the administration of fluids and blood pressure elevating agents if symptoms ensue. Rarely, during treatment, blood pressure might increase, thus necessitating the provision of antihypertensive agents or adjustments in the dialysis solution. This medication is used for hemodialysis in patients with chronic renal failure, especially suitable when metabolic acidosis is not improved with high-acetate dialysis solutions or when dialysis management is difficult. As this solution contains glucose, it is used for patients who find blood sugar management challenging. It is suitable for patients with hyperkalemia or hypercalcemia as it features low concentrations of potassium, calcium, and magnesium. Regular blood tests to monitor electrolytes, acid-base balance, renal function, and blood sugar levels are recommended. Women who are pregnant or may become pregnant should only use this medication when the benefits outweigh the risks. Safety for children has not been established, thus caution is advised. Elderly patients may be at risk for bone complications while using this medication, warranting regular clinical checks and vitamin D3 supplementation as needed. Overdosage may lead to alkali syndrome or hypokalemia, thus caution should be exercised. Dilution water for dialysis must be safe water that has undergone strict purification processes, with attention to potential membrane damage or bleeding tendencies. When preparing, do not directly mix the electrolyte solution for artificial kidney dialysis with sodium bicarbonate solution and adhere to prescribed methods and concentrations for dilution. Verify the electrolyte concentration, osmotic pressure, and pH level of the dialysis solution before use, discarding it if abnormalities or foreign substances are present. The dialysis solution should be used immediately and warmed to body temperature, with any remaining solution discarded after use. This medication should be administered under the instruction and supervision of a specialist experienced in dialysis to ensure safety.

Serious side effects

• Seizures
• altered consciousness
• symptoms of shock

Mild side effects

Hypoglycemia, hyperglycemia, weight gain, tendency for increased blood pressure, hypocalcemia, osteoporosis, osteomalacia, fibrous osteitis, ectopic calcification, symptoms of dialysis disequilibrium syndrome (headache, nausea, vomiting, discomfort, fatigue), hypotension, increased blood pressure, headache, palpitations, altered consciousness, limb paralysis, general fatigue, chest discomfort

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, preferably at room temperatures between 1 and 30 degrees Celsius. Storing it this way helps maintain its efficacy for a long time.

Appearance

A colorless, transparent artificial kidney dialysate solution filled in a polyethylene container with a smell of acetic acid

Package unit

10 liters/container