Prezol G (Aqueous)

Adult administration

1. The dilution preparation ratio of Prezol G (Aqueous) is mixed (this solution 1 : Prezol (B) 1.225 : purified water 32.775) to prepare a bicarbonate-type dialysis solution. 2. 5L should be infused through the artificial kidney blood dialysis supply device over an average period of 4 to 6 hours. 3. The dialysis time, frequency, and flow rate depend on the patient's condition and the specification of the artificial kidney machine.

This drug should not be used in patients with very low blood pressure or those with rapid heartbeat. Administration should also be avoided in patients with pulmonary edema or abnormal electrocardiograms, and in patients with high potassium levels in the blood. Additionally, it is advisable not to use this drug in patients with blood coagulation problems. Caution is necessary for patients with severe liver dysfunction or metabolic issues due to diabetes. Patients taking digitalis preparations should be aware of the risk of drug toxicity due to decreased potassium levels when using this drug. During or after dialysis, blood sugar may suddenly drop or rise, so it is essential to monitor blood sugar levels carefully and take immediate action if necessary. If there is an increase in fluid intake leading to weight gain or elevated blood pressure, appropriate treatment is required to regulate fluid balance in the body. Bone diseases such as osteoporosis or osteomalacia, or fibrous osteitis may occur due to calcium metabolism abnormalities, requiring proper treatment, such as supplementation with vitamin D3. Ectopic calcification may occur, necessitating treatment to maintain serum phosphorus levels within the normal range. If symptoms of dialysis disequilibrium syndrome such as headache, nausea, vomiting, cramps, or consciousness disturbances occur, measures to adjust dialysis efficiency may be required. It can affect the circulatory system, leading to symptoms of hypotension or shock, thus dialysis should be suspended or fluid and blood pressure-raising agents should be administered upon symptom occurrence. If blood pressure rises, it should be controlled by administering antihypertensive medications or changing the dialysis solution. This drug is used for hemodialysis in chronic renal failure patients and is suitable for dialysis when there is a lack of metabolic acidosis improvement or during episodes of hypotension and disequilibrium syndrome. Solutions containing glucose are used when blood sugar control is challenging and low potassium, calcium, and magnesium concentration dialysis is required. Periodic blood tests for electrolytes, acid-base balance, and blood sugar are essential during dialysis. The safety during pregnancy is not established, so women who are pregnant or may become pregnant should carefully consider the necessity and risks of treatment. The safety for children has not been confirmed, so caution is advised for use. Elderly patients may have a higher risk of bone complications, so regular examinations and vitamin D3 supplementation are recommended. In case of overdose, alkalosis or hypokalemia may occur, so caution is needed. Only strictly purified water should be used as dilution water for dialysis, and careful attention should be paid to the risk of dialysis membrane damage and bleeding. During preparation, do not mix artificial renal dialysis electrolyte solutions with sodium bicarbonate solutions, and ensure accurate dilution to the specified concentration. It is crucial to check the electrolyte concentration and pH of the dialysis solution before use, and to avoid using any solution that is abnormal or has expired. The dialysis solution should be used under the supervision of a specialist and is not intended for injection or peritoneal perfusion purposes. The dialysis solution should be used immediately after preparation and should be brought to body temperature for safe use.

Serious side effects

Consciousness disturbances, hypotension, palpitations, consciousness alterations, headache, cramps, vomiting, rash, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough + fever, yellowing of the skin or eyes (jaundice), extreme malaise, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, reduced urine output

Mild side effects

Hypoglycemia, hyperglycemia, weight gain, tendency to increase blood pressure, osteoporosis, osteomalacia, fibrous osteitis, ectopic calcification, symptoms of dialysis disequilibrium syndrome (headache, nausea, vomiting, cramps, discomfort, fatigue), hypotension, shock symptoms, increased blood pressure, headache, palpitations, consciousness disturbances, limb paralysis sensation, general malaise, chest discomfort, sudden drops in blood pressure

This drug may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius to preserve the effectiveness of the drug.

Appearance

A colorless and transparent artificial renal dialysis solution with a vinegar-like smell, filled in a polyethylene container.

Package unit

10L / container