Colazal Capsule (Balsalazide Sodium Trihydrate)

Adult dose

Induction therapy: Take 2.25g (3 capsules) 3 times daily until remission is achieved or for up to 12 weeks (6.75g per day). Maintenance therapy: The initial recommended dose is 1.5g (2 capsules) twice daily (3g per day). The dose may be adjusted according to the patient's response, and additional benefit may be achieved by increasing the dose to 6g per day. The capsules may be swallowed whole with water, or carefully opened and the contents mixed with applesauce. If a capsule is opened, the contents should be mixed with applesauce and taken immediately; the contents may be chewed if necessary. Do not leave this medicine mixed with applesauce for an extended period. Do not store the mixture for the next dose. When a capsule is opened, the contents may change color to orange-yellow due to a color change in the active ingredient. Taking the contents of an opened capsule may temporarily cause staining of the teeth or tongue.

Child dose

Children aged 5 to 17 years: Take 2.25g (3 capsules) 3 times daily for up to 8 weeks (6.75g per day). Children aged 5 to 17 years: Take 750mg (1 capsule) 3 times daily for up to 8 weeks (2.25g per day). Safety and efficacy have not been established for treatment lasting longer than 8 weeks.

This medication contains mesalamine, which may cause specific allergic reactions; therefore, individuals who are hypersensitive to this drug or mesalamine should not take it. Patients with severe liver damage or moderate to severe kidney impairment should also avoid using this medication. This drug should not be taken by patients with bleeding disorders or peptic ulcers, and by pregnant or nursing women. Asthma patients or persons with bleeding disorders, as well as those with mild kidney or liver disease, should use this drug with caution. During the use of this medication, regular blood tests, kidney function tests, and urine tests should be conducted. If any adverse symptoms such as bleeding, bruising, sore throat, fever, or fatigue occur, you should contact a doctor immediately. This medication may cause side effects primarily derived from mesalamine, including blood abnormalities, headaches, heart inflammation, shortness of breath, digestive disorders, liver function abnormalities, skin rashes, muscle pain, kidney inflammation, among others. Particularly, side effects similar to these may also occur in children aged 5 to 17, so caution is advised. It is recommended to take this medication with food as it favors absorption, and it may alter drug concentrations when taken with certain medications, so consultation with a doctor or pharmacist is necessary. It is safer for pregnant or nursing women to avoid taking this medication, and its use in children is only recommended for those over 5 years old. In cases of overdose, symptoms similar to salicylate poisoning may occur, so appropriate treatment is required based on the symptoms. Keep this medication out of reach of children, and do not transfer it to other containers to maintain its quality.

Blood disorders, aplastic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, headache, neuropathy, myocarditis, pericarditis, bronchospasm, allergic alveolitis, abdominal pain, diarrhea, nausea, vomiting, exacerbation of ulcerative colitis, acute pancreatitis, hepatitis, cholelithiasis, hepatotoxicity, jaundice, cholestatic jaundice, cirrhosis, hepatic necrosis, liver failure, alopecia, rash, systemic lupus erythematosus-like syndrome, arthralgia, myalgia, interstitial nephritis, epigastric pain, nasopharyngitis, fever, hematochezia, influenza, fatigue, gastritis, cough, sore throat, dysmenorrhea, nausea, rectal carcinoma

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. The recommended storage temperature is between 1°C and 30°C at room temperature to prolong the drug's effectiveness.

Appearance

A yellow to light orange powder contained in an off-white hard capsule.

Package unit

Bottle - 30 capsules/bottle, Bottle - 280 capsules/bottle