Hybigz Tablet (Clopidogrel Hydrogen Sulfate)

Adult dose

○ Adults 1. Patients with ischemic stroke, myocardial infarction, or peripheral arterial disease: Administer clopidogrel 75 mg orally once daily. 2. Patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction): On the day treatment with this drug is initiated, start with a loading dose of 300 mg once daily, followed by a maintenance dose of 75 mg orally once daily. Aspirin 75 ～ 325 mg should be administered once daily in combination with this drug. 3. Patients with atrial fibrillation: Administer 75 mg of this drug orally once daily. Aspirin 75 ～ 100 mg should be administered once daily in combination with this drug. ○ Patients with renal impairment : Treatment experience in patients with renal impairment is limited. ○ Patients with hepatic impairment : Treatment experience in patients with moderate liver disease and a bleeding diathesis is limited. This drug may be administered with or without food.

This drug helps prevent platelets in the blood from clumping together, thereby reducing the formation of blood clots. While taking this medication, the risk of bleeding may increase, so it might take longer for bleeding to stop. If symptoms such as bleeding, bruising, nosebleeds, or gum bleeding occur, notify a doctor immediately. Individuals with a genetic deficiency in a specific enzyme (CYP2C19) may experience reduced effectiveness from this medication and may have an increased risk of cardiovascular issues, thus should consult a physician. Additionally, taking this medication with certain drugs may raise the risk of bleeding, so it is crucial to inform your doctor or pharmacist about any other medications being taken. Patients with existing bleeding, severe liver damage, breastfeeding women, and those with lactose intolerance should not take this medication. If surgery or invasive procedures are planned, this medication should be discontinued 5 to 7 days prior and follow the doctor’s instructions. This drug can rarely cause thrombotic thrombocytopenic purpura (TTP), a serious blood disorder characterized by a rapid decrease in platelets. If sudden bleeding, fever, or neurological symptoms occur, visit a hospital immediately. During pregnancy or breastfeeding, consultation with a doctor is essential before taking this medication, especially since the risk of bleeding may increase during delivery. Elderly patients or those with impaired kidney function may have a higher risk of bleeding, thus dosage adjustments and monitoring of condition according to the doctor's direction are necessary. Overdose may significantly increase the risk of bleeding, therefore adhering to the prescribed dosage and administration is crucial. Keep this medication out of the reach of children and avoid transferring it to another container.

• Hemorrhage
• gastrointestinal bleeding
• hospitalization required bleeding
• purpura
• contusion
• hematoma
• epistaxis
• hematoma
• hematuria
• intraocular hemorrhage

This drug may be sensitive to air and moisture, so it should be stored in a sealed container. The recommended storage temperature is between 1 and 30 degrees Celsius at room temperature. This helps maintain the drug’s efficacy for a longer period.

Appearance

Pink round film-coated tablet

Package unit

For domestic use: 30 tablets/bottle, 300 tablets/bottle For export: 30 tablets (10 tablets/PTP × 3)