Aniseed Capsule (Omeprazole Enteric-Coated Granules)

Adult dose

Adults: 1) Gastric ulcer: Take 1 capsule (20mg) of omeprazole once daily. Most ulcers heal within 4 weeks, although the healing time may vary from patient to patient. If healing is incomplete after the first 4 weeks of treatment, continue treatment for another 4 weeks. In patients who have not responded to other medicines, 2 capsules (40mg) once daily generally result in healing within 8 weeks, although the healing time may vary from patient to patient. Repeat treatment if recurrence occurs. 2) Short-term treatment of duodenal ulcer: Take 1 capsule (20mg) once daily. Most ulcers heal within 2 weeks, although the healing time may vary from patient to patient. If healing is incomplete after the first 2 weeks of treatment, continue treatment for another 2 weeks. In patients who have not responded to other medicines, 40mg once daily generally results in healing within 4 weeks, although the healing time may vary from patient to patient. Repeat treatment if recurrence occurs. 3) Treatment of reflux esophagitis and symptoms of gastroesophageal reflux disease (GERD) (heartburn, regurgitation, etc.): - Reflux esophagitis: Administer 20mg orally once daily. Most cases heal within 4 weeks, although the healing time may vary from patient to patient. If healing is incomplete after the first 4 weeks of treatment, continue treatment for another 4 weeks. In patients who have not responded to other medicines, 40mg once daily generally results in healing within 8 weeks, although the healing time may vary from patient to patient. Repeat treatment if recurrence occurs. - Treatment of symptoms of gastroesophageal reflux disease (GERD) (heartburn, regurgitation, etc.): Administer 20mg orally once daily. Treatment for 2～4 weeks is generally sufficient for healing. 4) Maintenance treatment of severe reflux esophagitis and peptic ulcers that are difficult to treat: Administer 20mg orally once daily. If recurrence occurs, the dose may be increased to 40mg once daily. 5) Zollinger-Ellison syndrome: The initial dose is 60mg orally once daily. Continue treatment, adjusting the dose as appropriate for the individual. More than 90% of patients respond to doses of 20～120mg daily. If doses of 80mg or more are administered daily, divide the dose into 2 administrations per day. 6) Combination therapy with antibiotics to prevent recurrence of duodenal ulcers infected with Helicobacter pylori: - Dual therapy: Administer this medicine 20mg with amoxicillin 750-1000mg twice daily for 2 weeks. - Triple therapy: Administer this medicine 40mg once daily or 20mg twice daily in combination with the following antibiotics. ① Administer clarithromycin 250mg and metronidazole 400mg twice daily for 1 week, or ② Administer amoxicillin 1g and clarithromycin 500mg twice daily for 1 week. If the treatment response is insufficient, omeprazole monotherapy may be continued. 7) Treatment of gastric or duodenal ulcers or erosions caused by nonsteroidal anti-inflammatory drugs (NSAIDs): Administer 20mg orally once daily. Most cases heal within 4 weeks, although the healing time may vary from patient to patient. If healing is incomplete after the first 4 weeks of treatment, continue treatment for another 4 weeks. 8) Maintenance prevention of gastric or duodenal ulcers or erosions and dyspeptic symptoms caused by NSAIDs in patients receiving long-term NSAID treatment with a history of gastric or duodenal lesions: Administer 20mg orally once daily. 9) Prevention of recurrence of reflux esophagitis: Administer 10mg orally once daily to prevent recurrence of reflux esophagitis. Swallow this medicine whole with at least half a glass of water. Adjust the dose as appropriate according to age and symptoms.

This medication should not be used in patients with gastric ulcers who are allergic to any ingredient of this medication or have a possibility of malignant tumors. In particular, using this medication in patients with malignant tumors may lead to a delay in cancer diagnosis as symptoms may seem improved. Additionally, co-administration with certain antiviral drugs may reduce the effectiveness of the medication, so concurrent use should be avoided. Patients with poor liver function or the elderly should use this medication with caution and may require a dose reduction. When taking this medication, central nervous system side effects such as headache, dizziness, and drowsiness may occur, and liver function abnormalities or kidney issues may also arise. Gastrointestinal disturbances such as diarrhea, abdominal pain, and nausea may occur, as well as allergic reactions like skin rash or itching. In severe cases, symptoms such as shock, cardiac problems, decreased blood cell counts, and muscle pain may occur, so patients should consult a doctor immediately if any unusual symptoms appear. Long-term use of this medication may increase the risk of fractures and may lead to decreased magnesium levels, so regular monitoring is necessary. Additionally, this medication reduces gastric acid secretion, which may promote bacterial growth in the gastrointestinal tract and increase the risk of certain infections, so if diarrhea persists for a long time, a doctor's visit is warranted. During treatment with this medication, if there are any suspicious symptoms of malignancy, it is imperative to undergo testing, and if gastric cancer is confirmed, treatment must be discontinued. Interactions may occur when this medication is taken with other drugs, so patients must inform their doctor of any ongoing medications, especially with anticoagulants, anticonvulsants, and immunosuppressants. Pregnant women or those who could become pregnant should use this medication with caution, and breastfeeding should be avoided or halted if possible. Safety in children has not been established, so use is not recommended. In cases of overdose, symptoms such as vomiting, dizziness, and headache may occur, but they are usually temporary and severe side effects are rare. This medication should be stored out of reach of children, not transferred to different containers, and the cap should be securely closed after use. Finally, with long-term administration, there is an increased risk of developing specific tumors in the stomach, so it is important to use the minimum effective dose and duration as directed by a physician.

Headache, drowsiness, dizziness, insomnia, sensory disturbance, feeling faint, lightheadedness, confusion, agitation, aggression, hallucinations, depression, elevated liver enzymes, jaundice, hepatitis, liver failure, encephalopathy, interstitial nephritis, diarrhea, diarrhea with mucus, constipation, nausea, vomiting, abdominal pain, abdominal distension, dry mouth, stomatitis, gastrointestinal candidiasis, erythema, rash, urticaria, itching, dermatitis, vesicular rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, photosensitivity, alopecia, angioedema, fever, bronchospasm, interstitial nephritis, anaphylactic shock, chest pain, tachycardia, bradycardia, palpitations, leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, back pain, arthralgia, muscle weakness, myalgia, gynecomastia, cough, asthenia, fatigue, peripheral edema, increased sweating, visual haze, visual impairment, taste disturbance, breast pain in females, breast lump, hyponatremia, erectile dysfunction, Clostridium difficile-associated diarrhea, hypomagnesemia, acute generalized pustular psoriasis, drug reaction associated with eosinophilia and systemic symptoms, systemic lupus erythematosus, cutaneous lupus erythematosus, gastric polyp, hypocalcemia, hypokalemia

This medication should be stored in a tightly sealed container to prevent air or moisture ingress. Additionally, it is best to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

A hard capsule with a reddish-brown upper part and a pink lower part filled with pale yellow delayed-release granules.

Package unit

30 capsules/bottle, 100 capsules/bottle