Parlodel Tablets (Bromocriptine Mesylate)

Adult dose

Always administer immediately after a meal. The method of administration varies by condition, but for most indications, gradual dose escalation is desirable to minimize adverse reactions and achieve the maximum effect. The usual dose-escalation regimen is as follows. On the first day, administer 1.25mg of bromocriptine at bedtime. After the next 2∼3 days, administer 1.25mg in the morning and evening. Thereafter, increase the dose by 1.25mg every 2∼3 days until a maintenance dose of 2.5mg per dose twice daily is reached. If needed, increase the dose in the same manner (by 1.25mg every 2∼3 days). (Recommended doses by condition) ○ Prevention and suppression of lactation Administer according to the dose-escalation regimen above; the maintenance dose is 2.5mg of this medicine in the morning and evening. ○ Hypogonadism, galactorrhea, infertility Administer according to the dose-escalation regimen above. For most patients with hyperprolactinemia, a total daily dose of 7.5mg of this medicine in divided doses is sufficient, but the daily dose may be increased to 30mg if needed. For infertile patients without elevated serum prolactin levels, the usual dose is 2.5mg per dose twice daily. ○ Various symptoms of menstrual irregularities Administer according to the dose-escalation regimen above; the maintenance dose is 2.5mg per dose twice daily. ○ Acromegaly After administration according to the dose-escalation regimen above, increase the dose by 2.5mg every 2~3 days as follows. For 2∼3 days: 2.5mg per dose, 3 times daily For 2∼3 days: 2.5mg per dose, 4 times daily For 2∼3 days: 5mg per dose, 4 times daily ○ Parkinson’s disease Start with a low dose of 1.25mg at bedtime during the first week. Increase the dose by 1.25∼2.5mg at weekly intervals until the maintenance dose reaches 10∼15 mg per day. The usual dose for most patients is 10∼15mg per day, but it may be increased to 30∼40mg if needed. When this medicine is added to treatment in patients receiving levodopa, gradually reduce the levodopa dose while gradually increasing this medicine until the optimal balance is achieved. Adjust the dose appropriately according to age and symptoms.

This medication contains ergot alkaloids, so it should not be used by anyone who is already taking ergot alkaloids or has had allergic reactions to this medication or ergot alkaloids. Patients with severe heart or vascular problems, uncontrolled blood pressure, specific vascular diseases, or a history of mental disorders should also avoid this medication. Patients with very poor liver or kidney function, severe infections, specific vascular inflammation, or nicotine abusers should be cautious. This medication contains lactose, so those with lactose intolerance or specific genetic metabolic disorders should avoid it. Women who are pregnant or may become pregnant, patients with pituitary tumors affecting vision, patients with a history of liver or digestive diseases, and those with a history of mental disorders should use this medication cautiously. Special precautions are also necessary for individuals with a history of hypertension or heart disease, patients with kidney disease, children, and the elderly. Nursing mothers should avoid taking this medication as it can suppress breast milk secretion. While taking this medication, blood pressure fluctuations, dizziness, drowsiness, and sudden sleep occurrences may occur, so caution is needed when driving or operating machinery. Blood pressure should be monitored frequently during the initial period of administration, and any unusual symptoms should be observed. This medication may interact with various other drugs, so it's essential to consult a healthcare provider or pharmacist if you are taking other medications. Special caution is required when used in conjunction with antihypertensive agents, dopamine antagonists, certain antibiotics or antifungals, and antipsychotic drugs. Long-term high-dose use may cause fibrosis in pleura, lungs, and pericardium, so if related symptoms arise, medical consultation should be sought immediately. In case of overdose, symptoms such as vomiting, dizziness, hypotension, drowsiness, and hallucinations may appear, and immediate emergency treatment is necessary. During pregnancy, unless there is a specific reason, discontinuation of the medication should be considered, and women planning a pregnancy should periodically verify their pregnancy status through regular check-ups. The safety of this medication in children has not been established, so caution is especially needed when administering it to children. This medication should be stored out of reach of children and should not be taken arbitrarily or have its dosage altered.

• Sudden drop in blood pressure
• orthostatic hypotension
• nausea
• vomiting
• pallor
• cold sweat
• syncope
• dizziness
• fatigue
• fever

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is also advisable to keep it in a dark place to prevent exposure to light. The storage temperature should be maintained below 25 degrees to preserve the drug's efficacy.

Appearance

White round tablet

Package unit

30 tablets (10 tablets in PTP packaging x 3)