Mavid 250 mg Tablet (Clarithromycin)

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years and older: Same as adults For children under 12 years, use clarithromycin dry syrup.

This medication should not be used in patients with specific allergic reactions. For instance, patients who have had hypersensitivity reactions to this drug or similar classes of antibiotics should not be administered this medication. It is also safe not to administer this drug to patients with significant cardiac issues or severely reduced liver and kidney function. Special caution is needed for patients with prolonged QT intervals or a history of ventricular arrhythmias. Women who are pregnant or nursing should also refrain from taking this medication, and caution is warranted for young children under certain ages as adequate studies have not been conducted for its use in this group. This drug can interact with various medications, so it is crucial to consult a physician or pharmacist if other medications are being taken. Caution is particularly necessary when used with heart-related drugs, anticoagulants, specific antibiotics, antivirals, and hypoglycemic agents. During usage, allergic symptoms, skin rashes, severe gastrointestinal disturbances, respiratory difficulties, hearing changes, myalgia, and other unusual reactions may occur; thus, it is essential to inform healthcare professionals immediately if such symptoms arise. Long-term or excessive use of this drug may lead to hearing loss, tinnitus, liver dysfunction, kidney impairment, necessitating regular medical check-ups. Additionally, this medication should only be taken for the prescribed duration by a physician to prevent the development of resistant strains, and one should not arbitrarily discontinue or extend treatment. Lastly, caution is needed as this medication may cause dizziness or confusion when driving or operating machinery.

Shock, anaphylactic symptoms, dyspnea, convulsions, erythema, rash, itching, hives, skin redness, angioedema, joint swelling, drug-induced rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, epigastric pain, convulsion type, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbances, decreased appetite, constipation, fecal discoloration, membranous colitis, hemorrhagic colitis, fever, cough, chest X-ray abnormalities, eosinophilia, eosinophilic lung infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, increased total bilirubin, decreased appetite, dark urine, itching, abdominal tenderness, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, increased CPK, elevated serum myoglobin, increased urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, lethargy, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hypoglycemia, tinnitus, hearing impairment, vomiting, purpuric rash, acute generalized exanthematous pustulosis, soft tissue infection, candidiasis, gastroenteritis, infections, vaginitis, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, vascular edema, decreased appetite, insomnia, neuro-excitability, sound sensitivity, psychotic disorder, confused state, abnormal dreams, mania, movement disorders, non-vestibular dizziness, drowsiness, tremors, vestibular dizziness, hearing impairment, cardiac arrest, atrial fibrillation, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, increased alanine aminotransferase, increased aspartate aminotransferase, increased gamma-glutamyl transferase, liver failure, vesiculobullous dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schönlein purpura, muscle cramps, musculoskeletal rigidity, myopathy, elevated blood urea, injection site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased International Normalized Ratio, prolonged prothrombin time, abnormal urine color, changes in mental state, obsessive behavior, hypokalemia, hypoxemia

This medicine should be stored in a tightly closed container to prevent air ingress and kept in a dark place to avoid light exposure. The storage temperature should ideally be maintained between 1 degree and 30 degrees Celsius at room temperature.

Appearance

Yellow oblong film-coated tablet

Package unit

30 tablets/bottle