Hydepin Tablets (Felodipine)

Adult dose

Swallow this medicine whole with water. Do not divide, chew, or crush it. 1. Hypertension The initial dose of felodipine is 5㎎ orally once daily, and the maintenance dose is 5-10㎎ once daily in the morning. Do not exceed a maximum daily dose of 20㎎. This medicine may be administered concomitantly with a β-blocker or diuretic, or as monotherapy when other antihypertensive agents are inappropriate. Adjust the dose according to the patient's response to treatment. 2. Stable angina The initial dose is 5㎎ once daily and may be increased to 10㎎ as needed. This medicine may be administered concomitantly when a β-blocker does not provide an adequate effect. Adjust the dose according to the patient's response to treatment. 3. Elderly patients Administer with caution while monitoring the patient's condition; consider an initial dose of 2.5㎎ once daily. 4. Patients with renal impairment Renal impairment does not affect the plasma concentration of felodipine. Dose adjustment is not necessary, but administer with caution to patients with severe renal impairment (GFR<30ml/min). 5. Patients with hepatic impairment The plasma concentration of felodipine may increase in patients with hepatic impairment, and a therapeutic response may occur at a lower dose. Therefore, administer with caution to patients with hepatic impairment; consider an initial dose of 2.5mg once daily. Do not administer to patients with severe hepatic impairment.

Child dose

Safety and efficacy in children have not been established.

This drug should not be administered to women who are pregnant or may become pregnant. It is also not safe to use in patients with severely impaired cardiac function or those with acute myocardial infarction and unstable angina. Patients with severe liver or kidney dysfunction should use this drug cautiously and elderly patients also require careful consideration due to the risk of excessive blood pressure lowering. This drug should be avoided in individuals with allergies to lactose or certain colorants included in the formulation. When first taking this medication or increasing the dose, symptoms such as flushing of the face, headache, palpitations, dizziness, and fatigue may occur. Rarely, side effects such as excessively low blood pressure, edema, skin rash, muscle pain, gastrointestinal discomfort, and abnormal liver function may occur; if any unusual symptoms arise, consult a doctor immediately. Suddenly stopping this medication can worsen symptoms, so the dosage should be gradually decreased according to the doctor's instructions. If blood pressure drops too low, adjustments or discontinuation of the medication may also be necessary. Furthermore, since this drug is metabolized by a specific liver enzyme (CYP3A4), caution is needed when taken with other drugs that inhibit or activate this enzyme as it can alter drug concentrations. It is advisable to avoid taking it with grapefruit juice, as it can increase drug concentrations. It is preferable that pregnant or breastfeeding women do not use this drug, and safety for pediatric use has not been established. The elderly should start with a lower dose and take it under observation of their condition. In case of overdose, serious cardiovascular issues and neurological symptoms may occur, requiring immediate emergency care and appropriate treatment as directed by healthcare professionals. Finally, dizziness or fatigue may occur while taking this medication, so caution is advised when driving or operating hazardous machinery.

• Facial flushing
• headache
• palpitations
• dizziness
• fatigue
• tachycardia
• sensation of breathlessness
• chest tightness
• ankle swelling
• angina

This drug is sensitive to light, so it should be stored in a tightly closed container that does not allow light to penetrate. It's also important to maintain room temperature, between 1 degree and 30 degrees Celsius, when storing the drug. Proper storage will help maintain the drug's effectiveness over time.

Appearance

Pink, round, film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle