Livron tablets (tibolone)

Key information summary

Efficacy & effects

This medication is used to relieve symptoms of estrogen deficiency that occur in postmenopausal women. Additionally, it helps prevent osteoporosis in postmenopausal women at high risk of fractures who cannot use other osteoporosis preventive medications or are intolerant to them. This drug is effective for alleviating menopausal symptoms and preventing osteoporosis.

Dosage

This medication is taken as one tablet daily at the same time. The tablet should be taken with water or another beverage, and taking it at the same time every day is recommended. No dosage adjustment is necessary in the elderly.

Precautions

This medication should not be administered to certain patients. For example, patients allergic to any ingredient of this drug or women who are pregnant or may become pregnant, as well as nursing mothers, should not use this medication. Additionally, patients with or suspected of having estrogen-dependent tumors, cerebrovascular conditions or thromboembolic disorders, and those with a history of heart disease should not be given this medication. Patients with undiagnosed abnormal genital bleeding and those with liver function issues, as well as patients with endometriosis, should also refrain from using this medication. Since this drug contains lactose, it should not be administered to patients with lactose intolerance or related genetic disorders. Patients with poor kidney function, history of epilepsy or migraine, history of heart failure or hypertension, hypercholesterolemia, and those with carbohydrate metabolism disorders should use this medication with caution. In particular, it may affect blood sugar control, so dosage adjustments of insulin or antidiabetic medications may be necessary. During the course of this medication, various side effects may occur. For instance, after about a month of administration, vaginal bleeding or spotting may occur, and cases of endometrial hyperplasia or uterine cancer have been reported. Neurological symptoms such as dizziness, depression, headache, and migraine may also manifest. Gastrointestinal side effects may include gastrointestinal disturbances or abdominal pain, while musculoskeletal side effects may involve joint pain or muscle pain. Skin reactions could include rash, itching, seborrheic dermatitis, and increased facial hair growth, as well as vision disturbances such as blurred vision. Liver function test results may change, and cholestasis jaundice may develop, with an increased risk of thromboembolism. Additionally, symptoms such as weight changes or edema may be experienced. This medication is not a contraceptive and should not be used for that purpose. Administering it to premenopausal women may suppress ovulation and lead to irregular menstrual cycles, so it is not prescribed for premenopausal individuals. Regular examinations are necessary at least every six months when used with hormone therapy. Overdosage may lead to vaginal bleeding, and in case of high-dose administration, it is advisable to regularly administer progestogens. If there are signs of thromboembolism, liver dysfunction, or cholestasis jaundice, administration should be stopped immediately. This drug can affect blood coagulation, so caution is necessary during anticoagulant therapy. It should be discontinued at least four weeks before surgery if long periods of immobility are expected. Women over the age of 35 who smoke are at an increased risk of thromboembolism and liver tumors, thus regular check-ups are necessary. After menopause, the stimulation of the endometrium is lower; however, premenopausal women may experience temporary vaginal bleeding, so if bleeding continues or recurs during treatment, an examination is needed. This drug may have its efficacy reduced when taken with medications that induce specific liver enzymes, hence dosage adjustments may be necessary in such cases. It may also increase the fibrinolytic action in the blood, enhancing the effects of anticoagulants. It can impact blood sugar control, necessitating an increase in insulin or antidiabetic medications. Care should be taken as seizure control may become difficult when combined with some antiepileptics. Pregnant or potentially pregnant women and nursing mothers should not use this medication, as there have been reports indicating potential harm to the fetus from animal studies. In case of overdose, symptoms such as nausea, vomiting, and bleeding may appear, and since there is no specific antidote, appropriate treatment should be sought based on the symptoms. Finally, long-term use may lead to the development of liver tumors, which also poses a risk of intra-abdominal bleeding, so caution is warranted. High-dose hormone administration may increase the incidence of endometrial cancer and breast cancer, making regular check-ups essential.

Side effects

Cholestatic jaundice, thromboembolism

Alternatives / Same-ingredient medications

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  Libial Tablets (Tibolone)

  Same ingredient

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