Mepiryl Tablet (Glymepiride)

Adult dose

For patients who have never received medication before, the treatment starts at 1 mg of glymepiride once daily. If necessary, the dose may be increased by 1 mg every 1 to 2 weeks. Generally, no additional benefits are gained at doses above 4 mg; however, some patients may have better metabolic control with doses increased to 6 mg (or 8 mg). A daily dose of 4 mg is recommended for.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or in a comatose state. Patients who have previously experienced allergic reactions to this medication or its components should also not be administered this drug. It is not recommended for patients with severely impaired liver or kidney function, and switching to insulin therapy is recommended instead. Women who are pregnant or may become pregnant, as well as nursing women, should not take this medication. Insulin therapy may be necessary for patients with severe infections or those before and after surgery or severe trauma. Caution should be exercised as gastrointestinal disorders such as diarrhea or vomiting may impair food absorption and increase the risk of hypoglycemia. Patients with lactose intolerance or related genetic disorders should not use this medication. During the first week of taking this medication for the first time, the risk of hypoglycemia is high, so blood glucose levels should be monitored closely. This is especially true for the elderly, those in poor nutritional status, individuals with irregular eating patterns, and those who consume large amounts of alcohol. Caution is also advised when there is an imbalance in exercise and food intake. Patients with decreased liver or kidney function or other endocrine disorders may be more sensitive to hypoglycemia. Caution is also required if this medication is overdosed or used in combination with other medications. If hypoglycemic symptoms occur, sugar should be ingested immediately, and if symptoms are severe, the healthcare provider should be notified. This medication can cause various side effects such as hypoglycemia, blurred vision, dyspepsia, liver dysfunction, blood disorders, and allergic reactions. Notably, severe hypoglycemia can lead to a coma or seizures, so symptoms should be closely monitored. If allergic symptoms appear, the medication should be discontinued immediately and consulted with a physician. If liver dysfunction or blood disorder symptoms are suspected, the healthcare provider should be informed immediately. This medication must be accompanied by dietary and exercise therapy for blood glucose control and should be taken regularly to be effective. Always carry sugar to prevent hypoglycemic symptoms, and consume it immediately if hypoglycemia occurs. In stressful situations or illness, blood glucose control may become difficult and a switch to insulin therapy may be necessary. Regular tests of blood glucose and liver function should be performed during treatment, and if symptoms occur, consult with healthcare providers immediately. When taken with other medications, interactions may affect blood glucose control, so be sure to inform the healthcare provider of all medications being taken. Special attention is needed as some antibiotics, antifungals, beta-blockers, and steroids can affect blood glucose levels. Women who are pregnant or nursing should not take this medication as it may harm the fetus or newborn, and they should switch to insulin therapy if necessary. The safety of this medication in children under 18 has not been established, so its use is not recommended. Elderly patients may have decreased kidney function, so dosage adjustments are advised. In cases of overdose, severe hypoglycemia may occur, requiring immediate emergency treatment such as inducing vomiting, gastric lavage, or glucose injection, and close observation for at least 24 to 48 hours is necessary.

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in the mucus membranes of the mouth/eyes, shortness of breath or difficulty in breathing, asthma attacks, cough with fever and difficulty in breathing, yellowing of the skin or eyes (jaundice), profound lethargy, sudden severe headaches, lightning headache, seizures, disorientation, visual disturbances, paralysis, urinary issues.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or activity

This medication should be stored in a tightly closed container to protect it from air and moisture. It is best to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Green rectangular tablet

Package unit

30 tablets/bottle, 100 tablets/bottle