Concrin Tablet (Bisoprolol Fumarate)

Adult dose

Take orally with beverages on an empty stomach in the morning or during breakfast. 1. Hypertension, angina pectoris As bisoprolol fumarate, take 5-10 mg once daily orally. 5 mg is sufficient for mild cases while 10 mg is given for severe cases. In special cases, a maximum of 20 mg can be administered per day. Doses may be adjusted according to age and symptoms. In patients with liver or kidney impairment, do not exceed 10 mg daily in severe cases.

Child dose

There is no experience in using it in children, so administration is not recommended.

This medicine may not have experience in use for heart failure patients with certain diseases or conditions, so caution is required. For example, it should be administered carefully to patients with Type 1 insulin-dependent diabetes, severe kidney or liver dysfunction, and restrictive cardiomyopathy. Bronchodilators should be used in conjunction for patients with bronchial asthma or chronic obstructive pulmonary disease, and dose adjustment may be necessary for asthma patients as airway resistance may increase. This medication may increase sensitivity to allergens, so attention should be paid to allergy reactions, and in severe cases, adrenaline treatment may not be effective. Patients with psoriasis or a history of psoriasis should consider the risks and benefits of using this medication carefully. For patients with pheochromocytoma, this medicine should be administered after first giving an α-blocker. Thyroid dysfunction patients should be cautious as symptoms of hyperthyroidism may be masked by this medication. Regular check-ups are required at the initiation of treatment, and discontinuing this medication suddenly may worsen cardiac conditions, so dosage should be gradually reduced. This medication should not be used in patients with diabetic ketoacidosis, severe bradycardia, cardiogenic shock, acute heart failure, or severe hypotension. It is recommended not to administer during pregnancy or in women who may become pregnant due to risks to the fetus and newborn. During breastfeeding, as this medicine may be secreted in breast milk, it is necessary to avoid administration or discontinue breastfeeding while taking this medication. Safety in pediatric patients has not been established, so it is preferable not to use it. Elderly patients should start at a low dose and be administered carefully while monitoring their condition. This medication can interact with other drugs, so if other medications are being taken, it is essential to inform the physician, especially when combined with calcium antagonists, antiarrhythmics, and antihypertensives. Caution is advised while driving or operating machinery due to individual differences, especially at the beginning of treatment or when changing medications. In case of overdose, symptoms such as bradycardia, hypotension, bronchospasm, and worsening heart failure may occur, requiring immediate medical attention. This medication should be kept out of reach of children and stored in its original container to prevent quality degradation or misuse.

Serious side effects

• Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor
• → Severe allergic reaction
• Severe rash with high fever, blisters, skin peeling, pain in mouth/eyes mucosa
• → Severe skin adverse reaction
• Shortness of breath or difficulty breathing, asthma attack, abnormal breathing accompanied by cough + fever
• → Respiratory issues
• Yellowing of the skin or eyes (jaundice), profound lethargy
• → Liver abnormalities (jaundice)

Mild side effects

• Cardiovascular: Bradycardia, worsening heart failure, coldness or numbness in limbs, hypotension, atrioventricular conduction disturbances, orthostatic hypotension
• Neurological: Dizziness, headache, sleep disturbances, depression, nightmares, hallucinations
• Gastrointestinal: Nausea, vomiting, diarrhea, constipation
• General: Weakness, fatigue
• Respiratory: Bronchospasm, allergic rhinitis
• Musculoskeletal: Muscle atrophy and cramps
• Eyes: Decreased tear production, conjunctivitis
• Ears: Hearing impairment
• Skin: Hypersensitivity reactions (itching, redness, rash)

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained at room temperature between 1°C and 30°C. Storing it this way can safely maintain the medication's effectiveness.

Appearance

Light yellow, film-coated tablet with a heart shape that is convex on both sides and has a notch on one side.

Package unit

30 tablets/bottle, 300 tablets/bottle