Serant Tablet (Cefprozil Hydrate)

Adult dose

○ Adults (13 years and older) 1) For pharyngitis and tonsillitis among upper respiratory tract infections, administer cefprozil 500mg (potency) every 24 hours; for acute sinusitis, administer 250mg (potency) or 500mg (potency) every 12 hours (dose increase is needed for moderate or more severe infections). 2) For bacterial superinfection of acute bronchitis or bacterial exacerbation of chronic bronchitis among lower respiratory tract infections, administer 500mg (potency) of this drug every 12 hours. 3) For uncomplicated skin and soft tissue infections, administer 250mg (potency) of this drug every 12 hours [or 500mg (potency) every 24 hours], or administer 500mg (potency) every 12 hours depending on the symptoms. 4) For uncomplicated urinary tract infections, administer 500mg (potency) of this drug every 24 hours. <Duration of administration> Treatment is usually administered for about 10 days; however, for pharyngitis/tonsillitis caused by Streptococcus pyogenes (Group A beta-hemolytic), administer for 10 days or longer. For uncomplicated cystitis, administer for about 7 days. ○ Patients with renal impairment 1) If creatinine clearance is 30～120mL/min, administer according to the standard dosage and administration above. 2) If creatinine clearance is 29mL/min or less, administer 50% of the standard dose at the same interval as the standard regimen. However, since some of this drug is removed by hemodialysis, administer it after hemodialysis is completed. Once reconstituted, refrigerate and use within 14 days (syrup formulation only).

Child dose

○ Children (2～12 years) — Pharyngitis and tonsillitis among upper respiratory tract infections: administer 7.5mg (potency) per Kg of body weight per dose every 12 hours. ○ Children (2～12 years) — Uncomplicated skin and soft tissue infections: administer 20mg (potency) per Kg of body weight per dose every 24 hours. ○ Infants and children (6 months～12 years) — Otitis media among upper respiratory tract infections: administer 15mg per Kg of body weight every 12 hours. ○ Infants and children (6 months～12 years) — Acute sinusitis: administer 7.5mg per Kg of body weight every 12 hours. ○ Infants and children (6 months～12 years) — Acute sinusitis, moderate or more severe infection requiring a dose increase: administer 15mg per Kg of body weight every 12 hours.

This medication should not be used in patients with hypersensitivity to cephalosporins. Patients with a history of allergy to penicillin or other medications should use this medication with caution, especially patients with decreased kidney function should meticulously check their renal status before and after treatment. Patients with impaired kidney function should have their dosage adjusted, and patients with gastrointestinal disease should also exercise caution. When taking this medication, gastrointestinal issues such as diarrhea, nausea, vomiting, abdominal pain, as well as liver dysfunction, rashes, and allergic reactions may occur, and if these symptoms arise, immediate consultation with a healthcare professional is necessary. Central nervous system symptoms such as dizziness, headache, and drowsiness have been reported rarely, and seizures may occur occasionally, so caution is required. Blood tests may show decreased white blood cell counts or elevated renal function markers, so regular testing is essential. Due to the possibility of developing antibiotic resistance with prolonged use, this medication should only be taken for the period prescribed by a healthcare professional, and appropriate action should be taken if another infection occurs during treatment. If any allergic reactions occur, the medication should be immediately discontinued and emergency treatment sought. If diarrhea occurs after taking antibiotics, treatment should be given with consideration for the possibility of pseudomembranous colitis. Caution should be taken when taken together with other cephalosporins or certain diuretics, as they may burden the kidneys. During pregnancy, this medication should only be used when necessary, and in nursing mothers, it should be used cautiously considering its potential impact on the infant. It is advisable not to use this medication in infants under 6 months of age due to lack of safety data. Elderly patients may require dosage adjustments due to decreased kidney function. This medication may affect the results of certain tests, so it is important to inform medical personnel prior to testing. In the case of overdose, since it is excreted through the kidneys, it can be removed by hemodialysis if renal function is impaired.

• Diarrhea
• nausea
• vomiting
• abdominal pain
• elevated AST
• elevated ALT
• elevated ALP
• increased bilirubin levels
• rash
• urticaria

This medication is sensitive to light, so it should be stored in a light-protective container. Additionally, to maintain the medication's efficacy, it is important to store it at a temperature between 1 to 30 degrees Celsius.

Appearance

Yellow-orange film-coated tablet in an oblong shape

Package unit

30 tablets/bottle, 100 tablets/bottle