Glimepiride Tablet

Adult dose

Individual adjustments for each patient. Swallow without chewing with more than 1/2 cup of water. Administer orally once a day. It should be taken before breakfast or immediately before the first meal, and it is essential not to skip meals after taking it. The initial dose for monotherapy is 1 mg of glimepiride once daily. If necessary, the dose can be increased by 1 mg at intervals of 1 to 2 weeks, typically no more than 4 mg.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or diabetic coma. Patients who have had allergic reactions to this medication or its components, or to sulfonylureas or sulfonamides should not take this medication. It is not recommended for patients with severe liver or kidney dysfunction, and it is better to switch to insulin therapy for blood sugar control. Pregnant women or women of childbearing potential, as well as nursing mothers, should not take this medication and should switch to insulin therapy if necessary. Patients with severe infections, during and after surgery, or with severe trauma are advised to use insulin therapy and should avoid this medication. In cases of gastrointestinal disorders such as diarrhea or vomiting, proper absorption of food may be impaired, increasing the risk of hypoglycemia, so caution is needed. This medication contains lactose, so it should not be taken by patients with lactose intolerance or genetic lactose metabolic disorders. During the first week of administering this medication, the risk of hypoglycemia is high, so blood sugar should be monitored closely. Especially for elderly patients, those who have difficulty cooperating, those in poor nutritional status or skipping meals, and patients with irregular exercise and dietary patterns, the risk of hypoglycemia is elevated. Patients who consume alcohol, or have kidney or liver dysfunction may also be more sensitive to hypoglycemia, so caution is required. Additionally, those with other endocrine disorders or those who have overdosed on medications, or patients taking multiple drugs simultaneously should be attentive to the risk of hypoglycemia. Due to its blood sugar-lowering effect, this medication may cause the symptoms of hypoglycemia. Symptoms of hypoglycemia may include headache, severe hunger, nausea, fatigue, drowsiness, anxiety, confusion, vision problems, trembling, dizziness, loss of consciousness, etc. In severe cases, it can lead to seizures or coma, so if hypoglycemic symptoms occur, immediate intake of sugar or notification of healthcare professionals is necessary. During initial dosing, blurred vision, gastrointestinal symptoms, liver function abnormalities, blood abnormalities, and allergic reactions may rarely occur, so patients should be monitored closely. Allergic symptoms may include itching, rash, shortness of breath, and if these symptoms appear, immediate notification to a doctor is necessary. This medication should be taken regularly along with dietary management, exercise, and weight control to achieve optimal blood sugar control. If hypoglycemia occurs, it can be quickly treated by consuming sugar or sugar-containing beverages, so patients should always carry sugar. It is important to thoroughly educate patients and their families about the symptoms of hypoglycemia and risk factors. During treatment, regular monitoring of blood sugar and urine glucose tests should be done to check the effectiveness of the medication, and dosage adjustments or changes to treatment may be necessary as needed. Moreover, during the initial administration or when changing medications, behavioral changes due to hypoglycemia or hyperglycemia may occur, so caution is advised when driving or operating machinery. This medication may interact with other medications, so if patients are taking other drugs, they should inform their doctor or pharmacist. Certain antibiotics, antifungals, blood pressure medications, antidepressants, anticoagulants, and steroids may particularly affect blood sugar control. Drugs like beta-blockers may mask warning signs of hypoglycemic symptoms, so caution is required. Alcohol consumption may also affect the blood sugar-lowering effect of this medication, so it is recommended to avoid it. Pregnant or nursing women should not use this medication as it may pose risks to the fetus or newborn, and it is safer to consult with a doctor and switch to insulin therapy. For children under 18 years of age, the safety and efficacy of this medication have not been established, so its use is not advisable. Elderly patients may have decreased kidney function, so the dosage of this medication should be carefully adjusted, and particular attention should be paid to the risk of hypoglycemia. In cases of overdose, severe hypoglycemia may occur, so immediate hospital visit for emergency treatment is necessary. Inductions of vomiting, gastric lavage, administration of activated charcoal, etc., may be required, and intravenous glucose may be administered to rapidly restore blood sugar to normal ranges.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash accompanied by high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, lightning headache, seizures, confusion of consciousness, visual abnormalities, paralysis, and significantly reduced urine output.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or mobility

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is recommended to keep the storage temperature between 1 degree and 30 degrees Celsius at room temperature. This way, the effectiveness of the medication can be maintained for a longer period.

Appearance

Green rectangular tablet

Package unit

30 tablets/bottle, 200 tablets/bottle