Simvax Tablets (Simvastatin)

Adult dose

Reduction of risk for cardiovascular diseases: recommend 40 mg once daily in the evening. For hyperlipidemia: typically, an initial dose of 20 mg; mild to moderate hypercholesterolemia can start at 10 mg, administered 5-40 mg once daily in the evening. Recommended specific dosages: - for homozygous familial hypercholesterolemia: 40 mg daily in the evening; - elderly: 20 mg daily; - for verapamil.

Child dose

Heterozygous familial hypercholesterolemia pediatric patients (10-17 years): administer 10 mg once daily in the evening. Recommended dosage range is 10-40 mg daily, with a maximum of 40 mg. Dose adjustments should be made after at least 4 weeks of initial administration.

This medication primarily works in the liver to lower blood cholesterol levels. Patients should be cautious as muscle-related side effects such as myalgia or muscle weakness may occur during treatment. The risk of muscle disease and rhabdomyolysis may increase, especially when taken at high doses or combined with other medications. Therefore, for high doses, the physician may adjust to a lower dose or change medications according to guidance. This medication may affect liver function, and it should not be taken by individuals with liver disease or abnormal liver function tests, and regular liver function tests should be conducted during treatment. Pregnant or breastfeeding women should not take this medication, and women of childbearing age must ensure contraception if there is a possibility of pregnancy. Additionally, the risk of side effects may increase when taken with certain antibiotics, antifungals, and immunosuppressants that inhibit the CYP3A4 enzyme, so consult a doctor if there are any concomitant drugs. Elderly patients, those with kidney disease, and those with hypothyroidism are at higher risk for muscle disease, requiring additional caution. If unexplained muscle pain, tenderness, or weakness occurs during treatment, inform the physician immediately, and the medication may need to be discontinued if symptoms are severe. Taking this medication with grapefruit juice should be avoided as it may increase blood drug concentration and the risk of side effects. This medication is not recommended for children, especially those under 10 years old or pre-menarchal females. If overdose occurs, seek immediate medical attention for proper treatment, typically based on symptoms. Lastly, it is important to store this medication out of reach of children and keep it in its original container, avoiding transfer to other containers.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, jaundice (yellowing of the skin or eyes), extreme fatigue, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, change in urine output,

Mild side effects

• Abdominal pain
• weakness
• constipation
• diarrhea
• indigestion
• bloating
• nausea
• headache
• upper respiratory infection
• atrial fibrillation

Store this medication in a tightly closed container that is not exposed to air, preferably at room temperature between 1 and 30 degrees Celsius. This will help maintain the medication's efficacy for a longer period.

Appearance

Yellowish-brown oval film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle