Clothin Tablets (Clarithromycin)

Adult dose

Adults: The usual dose of clarithromycin is 250 mg (potency) per dose 2 times daily; for severe infections, administer 500 mg (potency) per dose 2 times daily. The usual treatment duration is 7–14 days. In patients with renal failure and creatinine clearance of 30 mL/min or less, the dose should be reduced by half: 250 mg (potency) once daily, or, for severe infections, 250 mg (potency) per dose 2 times daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500 mg (potency) per dose 2 times daily. In this case, it should be administered concomitantly with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer clarithromycin 500 mg (potency) 3 times daily for 14 days in combination with omeprazole 40 mg once daily, followed by omeprazole 40 mg once daily for 14 consecutive days. That is, administer clarithromycin 500 mg (potency) per dose 3 times daily for 14 days (days 1–14), and omeprazole 40 mg once daily for 28 days (days 1–28). Children 12 years of age and older: same as adults.

Child dose

For children under 12 years of age, use clarithromycin dry syrup.

This drug should not be used in patients with allergies to certain ingredients or those who have had hypersensitivity reactions to macrolide antibiotics. Caution should be taken when taking this medication with other drugs that may affect heart rhythm, as it could increase the risk of arrhythmias. In patients with severely impaired liver or kidney function, administration should be avoided or doses adjusted. It is advisable for pregnant or breastfeeding women to avoid taking this drug. This medication can rarely cause severe allergic reactions, skin diseases, liver dysfunction, kidney problems, or central nervous system symptoms, so if any unusual symptoms occur, consult a doctor immediately. It has significant interactions with other drugs; therefore, inform healthcare providers of any medications being taken, and regularly monitor for changes in drug concentration or side effects. Care should be taken as prolonged or high-dose usage may lead to hearing impairment or tinnitus. If gastrointestinal symptoms such as diarrhea or abdominal pain persist, it could signal a serious condition such as pseudomembranous colitis, requiring immediate cessation of use and consultation with healthcare providers. Elderly patients should be administered cautiously, as the drug may remain in the body longer due to reduced bodily functions. During the intake of this medication, dizziness or confusion may occur when driving or operating machinery, so caution is advised.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, epigastric pain, convulsive form, thirst, tooth discoloration, pancreatitis, amylase increase, taste disturbance, loss of appetite, constipation, discoloration of stool, membranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, AST elevation, ALT elevation, γ-GTP elevation, LDH elevation, ALP elevation, total bilirubin increase, loss of appetite, dark urine, itching, abdominal tenderness, increased serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, malaise, elevated CPK, elevated serum myoglobin, elevated urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, abnormal sensation, arthralgia, myalgia, olfactory dysfunction, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute pancreatitis, increased amylase, AST elevation, ALT elevation, elevated BUN, thrombocytopenia, leukopenia, prolonged prothrombin time, vasodilation, cardiac arrest, atrial fibrillation, ECG QT prolongation, ectopic beats, palpitations, ventricular fibrillation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, bile stasis, hepatitis, alanine aminotransferase elevation, aspartate aminotransferase elevation, gamma-glutamyl transferase elevation, liver failure, rash, diaphoresis, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura, acute generalized exanthematous pustulosis, muscle cramps, musculoskeletal rigidity, myopathy, increased serum creatinine, increased urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color

This drug may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is best to maintain room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the drug's efficacy and safety for a longer period.

Appearance

Yellow oblong film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle