Wonpolmin Tablet (Metformin Hydrochloride)

Adult dose

The dosage should be determined based on individual drug effectiveness and tolerance and should not exceed the recommended maximum daily dosage. Start with a low dose and administer 500 mg two to three times daily with meals. The dosage may be gradually increased by 500 mg weekly, and when administering 2000 mg, it is generally divided into two doses taken in the morning and evening. If exceeding 2000 mg, the medication should be divided into three doses with meals, up to a maximum daily dosage of 2550 mg. Blood glucose should be checked in a fasting state to measure treatment response and confirm the minimum effective dose when initiating treatment and adjusting dosage. Hemoglobin A1c levels should be measured approximately every three months. The treatment goal of this medication is to either be administered as monotherapy or in combination with sulfonylureas or insulin at the minimum effective dosage to reduce fasting blood sugar and hemoglobin A1c levels to normal or nearly normal levels. Generally, in patients whose blood sugar was controlled solely by diet, the short-term administration of this medication can provide sufficient effect if they temporarily experience uncontrolled blood sugar. For children and adolescents in growth, this medication can be used for those aged 10 and older. The typical initial dosage is 500 milligrams once daily, administered during or after meals. Blood sugar levels should be measured one week later to adjust the dosage. Gastrointestinal side effects may improve with gradual dosage increases. The maximum daily dosage is 2000 mg, and this dosage should be divided into two to three doses. In patients with renal impairment, this medication can be used under the following dosage adjustment, without causing additional symptoms that increase the risk of lactic acidosis. - The starting dose is 500 mg or 850 mg once daily. The maximum daily dosage is 1000 mg, divided into two doses. Renal function should be closely monitored every 3 to 6 months. If creatinine clearance or glomerular filtration rate falls below 45 mL/min or 45 mL/min/1.73 m², the medication should be immediately discontinued.

Child dose

Can be used in children aged 10 and older or adolescents during growth. The typical initial dosage is 500 milligrams once daily, administered during or after meals. Blood sugar levels should be measured one week later to adjust the dosage.

This medication can cause lactic acidosis, a dangerous condition that results from excessive accumulation of lactic acid in the body, and should not be used in patients with severe renal impairment, acute heart disease, infections, or dehydration. Additionally, this medication should be temporarily discontinued before acute heart failure or certain radiologic examinations, and patients who have had allergic reactions to this medication or similar drugs should not take it. The use of this medication should be carefully considered in pregnant patients or those with severe liver dysfunction, and in patients with severe infections or trauma that negatively impact their health. Patients should be cautious of low blood sugar risks during treatment if they skip meals, excessively exercise, or take this medication with other drugs. Common side effects include gastrointestinal symptoms such as diarrhea, nausea, and vomiting, which typically appear in the early stages of treatment and resolve naturally over time. Rarely, side effects such as decreased vitamin B12 levels in the blood, liver dysfunction, skin rashes, and hypoglycemia may occur, so regular testing is necessary. Renal function should be monitored regularly during treatment, and if renal function declines, the use of this medication should be discontinued. Moreover, the risk of lactic acidosis may increase if this medication is taken with alcohol, so it is advisable to avoid drinking. The effects of this medication on the fetus during pregnancy are not fully understood, so it should only be used after consulting with a doctor if pregnancy is planned or occurs. As this medication is secreted into breast milk, careful consideration should be given to whether to continue breastfeeding or discontinue medication. Elderly patients may experience decreased renal function, so dosage adjustments and regular monitoring of renal function are necessary. In cases of overdose, the medication can be removed through hemodialysis, so patients should seek immediate medical attention. Finally, this medication may interact with other hypoglycemic agents, so patients must inform their doctor or pharmacist about any other medications they are taking.

Serious side effects

Lactic acidosis, severe allergic reactions (hives, significant swelling), severe skin reactions (high fever and severe rash, blisters, skin peeling, mucosal pain), respiratory problems (difficulty breathing, asthma attacks, cough with fever accompanied breathing problems), liver issues (jaundice of the skin or eyes, systemic lethargy), severe neurological symptoms (sudden and very severe headaches, seizures, confusion, vision disturbances, paralysis), severe swelling or abdominal pain

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain), unpleasant or metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver dysfunction, hypoglycemia

This medication should be stored in a tightly closed container to protect it from air and moisture. It is advisable to maintain storage temperatures between 1°C and 30°C at room temperature. This helps to preserve the drug's effectiveness and safety for an extended period.

Appearance

White round film-coated tablet

Package unit

300 tablets/bottle