Mericl Tablet (Glimepiride)

Adult dose

Administer orally once a day. It should be taken before breakfast or right before the first meal. The initial dose starts at 1 mg of glimepiride and can be increased by 1 mg at intervals of 1 to 2 weeks. Generally, dosages above 4 mg exhibit little additional effect, although in some cases, it can be increased to a maximum of 6 to 8 mg. If a daily dose of 4 mg fails, consider switching to insulin therapy or co-administration.

This medication should not be used in patients with insulin-dependent diabetes or those experiencing diabetic ketoacidosis or coma. Patients with allergies to this medication, its components, or sulfonylureas should also refrain from taking it. It is not to be used in patients with severely diminished liver or kidney function, and insulin therapy is recommended in such cases. Women who are pregnant or may become pregnant, as well as nursing mothers, should not take this medication. Patients with severe infections, or those undergoing surgery or suffering from serious trauma should also be recommended insulin therapy instead of this medication. Patients with gastrointestinal disorders such as diarrhea or vomiting are at risk for hypoglycemia due to poor food absorption, so caution is needed. During the initial week of treatment, there is a high risk of hypoglycemia, so blood sugar levels should be carefully monitored, particularly in the elderly, those with poor nutritional status or irregular eating habits, and patients who consume alcohol frequently. Patients with weakened kidney or liver function, or those with other endocrine disorders or excessive medication use also face an increased risk of hypoglycemia that necessitates careful management. This medication may cause hypoglycemia, with symptoms including headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, and loss of consciousness. If hypoglycemic symptoms occur, sugar should be ingested immediately, and consultation with medical personnel should follow. Various side effects can occur, including blurred vision, indigestion, liver dysfunction, blood abnormalities, and allergic reactions. Therefore, any abnormal symptoms should be reported to a doctor immediately. This medication must be taken regularly alongside dietary and exercise regimens, and it is essential to consistently confirm blood sugar control. In the event of hypoglycemia, consumption of sugar or sugar-containing drinks can alleviate symptoms, so it is advisable to always carry some form of sugar. When taking this medication alongside other drugs, it may affect blood sugar control due to interactions, so patients must inform their doctor or pharmacist about all medications they are taking. In particular, since this medication is metabolized in the liver, dosage adjustments may be necessary when used with drugs that affect liver metabolism. Pregnant or nursing women should avoid this medication to prevent harm to the fetus or newborn and switch to insulin therapy as a safer option. Children should not use this medication as its safety and efficacy have not been established for them. Elderly patients may have delayed excretion of the medication due to decreased kidney function, necessitating careful dose adjustments. In the case of overdose, severe hypoglycemia may occur, requiring immediate emergency treatment such as inducing vomiting, gastric lavage, or glucose injection.

Serious side effects

• Hives, severe swelling (edema), difficulty breathing, chest tightness, cold sweat, paleness → Severe allergic reaction
• Severe rash with fever, blisters, skin peeling, pain in mouth/eye mucosa → Severe skin reaction
• Yellowing of skin or eyes (jaundice), extreme fatigue → Liver abnormalities (jaundice)
• Seizures, loss of consciousness, and coma → Serious neurological symptoms
• Thrombocytopenia, leukopenia, hemolysis

Mild side effects

Headache, severe hunger, nausea, vomiting, fatigue, sleep disturbances, anxiety, aggressiveness, decreased concentration, depression, confusion, speech difficulties, aphasia, visual disturbances, tremors, incomplete paralysis, sensory disturbances, dizziness, lethargy, loss of self-control, temporary confusion, drowsiness, bradycardia, tachycardia, hypertension, palpitations, angina, venous arrhythmia, blurred vision, feelings of fullness in the upper abdomen, abdominal pain, diarrhea, itching, rash, taste abnormalities, hair loss, weight gain,

This medication should be stored in a sealed container to prevent exposure to air or moisture. It is best to keep it at room temperature between 1 and 30 degrees Celsius. This helps maintain the medication's efficacy for a longer period.

Appearance

Green oblong tablet

Package unit

Domestic: 30 tablets (10 tablets/PTP x 3), 300 tablets/bottle, Export: 30 tablets (10 tablets/PTP x 3)