Carmen Tablet 5 mg (Carbimazole)

Adult dose

1. Adults 1) Initial dose: Administer 20 ∼ 60 mg orally per day and continue treatment until thyroid function becomes normal. 2) Subsequent treatment (1) Maintenance therapy: Adjust the dose as appropriate to maintain normal thyroid function, with a final dose of 5 ∼ 15 mg per day. Continue treatment for at least 6 months to 18 months. Ongoing monitoring of thyroid function is recommended, with appropriate dose changes as needed to maintain a euthyroid state. (2) Block-and-replace therapy: Maintain a dose of 20 ∼ 60 mg per day and administer iodothyronine concomitantly at 50 ∼ 150 μg per day to prevent hypothyroidism. Continue treatment for at least 6 months to 18 months. 3. Elderly patients: Although no special dosage regimen is required, the risk of potentially fatal outcomes such as neutropenia is higher in elderly patients (65 years and older); therefore, use with caution, taking the precautions for use into consideration.

Child dose

2. Children: The usual initial dose is 15 mg per day.

This medication should not be used in certain patients. For example, patients who are allergic to this medication or its components, have a history of severe blood disorders, have thyroid cancer, have severely impaired liver function, or are breastfeeding should avoid use. Additionally, it should be used with caution in patients with liver or kidney problems or in cases where the goiter is large enough to compress the trachea. Mild side effects such as nausea, headache, dyspepsia, skin rash, and arthralgia may appear during treatment, but most patients can continue treatment. However, serious symptoms such as severe blood disorders, liver dysfunction, acute pancreatitis, and severe allergic reactions may occur rarely, so if any of these symptoms appear, the medication should be discontinued immediately, and a doctor should be consulted. This medication can cause a fatal blood disorder called agranulocytosis, so if symptoms such as sore throat, bleeding, or signs of infection appear, medical personnel should be informed immediately, and regular blood tests should be conducted. During pregnancy, it may affect the fetus, so it should only be used at the minimum dosage when absolutely necessary, and women who might become pregnant should ensure effective contraception during the treatment period. Breastfeeding women should either stop breastfeeding or avoid use of this medication, as it can be transmitted into breast milk and affect the newborn. This medication may interact with other drugs, so if you are taking other medications, it is essential to inform your doctor or pharmacist, especially when used together with anticoagulants or certain thyroid treatments, caution is required. In case of overdose, thyroid function suppression or worsened blood abnormalities may occur, so prescribed dosages must be strictly adhered to, and it should be stored in a safe place out of reach of children.

• Nausea
• headache
• mild indigestion
• skin rash
• joint pain
• itching
• hair loss
• bone marrow suppression
• agranulocytosis
• hypoprothrombinemia

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain storage temperatures between 1 degree and 30 degrees Celsius.

Appearance

White rectangular film-coated tablet

Package unit

Domestic use - 300 tablets/bottle, Domestic use - 90 tablets/bottle, Export use - 100 tablets/box [(10 tablets/PTP×10)], Export use - 100 tablets/bottle