Roglic (Glimepiride) Tablets

Adult dose

Administer 1 time daily orally. Swallow with more than 1/2 cup of water without chewing. Take before breakfast or immediately before the first meal. The initial dosage starts at 1 mg of glimepiride once daily, increasing by 1 mg at intervals of 1 to 2 weeks. Generally, there is little additional benefit above a dosage of 4 mg, but it can be increased up to 6 mg or 8 mg. The standard dosage is 4 mg.

This medication should not be used in patients with type 1 diabetes, diabetic ketoacidosis, or those in a comatose state. It should not be administered to individuals with an allergy to this drug or its components, or similar medications. There is no experience with use in patients with severe liver or kidney dysfunction, so switching to insulin therapy is recommended. It is safer for pregnant women, women of childbearing potential, and nursing mothers to avoid this medication. Insulin therapy is recommended for patients with severe infections, pre- and post-surgical states, or severe trauma. Patients with gastrointestinal disturbances such as diarrhea or vomiting may have inadequate food absorption, leading to a risk of hypoglycemia, thus caution is advised. During the first week of administration, the risk of hypoglycemia is high, so blood sugar should be monitored closely. Particularly careful monitoring is required for the elderly, patients with poor nutritional status, those with irregular meal patterns, incongruent exercise and carbohydrate intake, changes in eating habits, frequent alcohol consumption, patients with decreased kidney and liver function, and patients who have overdosed on this medication. Moreover, caution is needed for patients with endocrine disorders such as thyroid or adrenal disease or those taking other medications. Due to its blood sugar-lowering action, this medication can cause hypoglycemic symptoms. Symptoms of hypoglycemia may include headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, and decreased consciousness, and in severe cases, may lead to coma. Additionally, symptoms such as blurred vision, gastrointestinal disturbances, abnormal liver function, blood abnormalities, and allergic reactions may occur, and immediate consultation with medical personnel is required if any abnormal symptoms appear. While taking this medication, regular meals and exercise should be maintained, and blood sugar control should be monitored consistently. It is important to be prepared to quickly counteract hypoglycemia by consuming foods containing sugars. Also, if blood sugar control becomes difficult due to stressful situations, surgeries, or infections, transitioning to insulin therapy may be necessary. This medication can interact with other medications, so patients must inform their physician or pharmacist about any other medications being taken. Particularly, caution should be exercised when co-administering with medications metabolized in the liver, as this may affect blood sugar control. Pregnant or nursing women should consider insulin therapy instead of this medication as it may affect the fetus or newborn. In case of overdose, severe hypoglycemia can occur, requiring immediate emergency treatment including induced vomiting, gastric lavage, or intravenous glucose administration.

Serious side effects

Rash, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in the mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, cough accompanied by fever and respiratory abnormalities, jaundice (yellowing of the skin or eyes), profound lethargy, sudden and severe headaches, lightning headaches, seizures, confusion of consciousness, visual disturbances, paralysis, urination changes.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• reduced agility or activity

This medication should be stored in a tightly sealed container that allows minimal air exposure, preferably at a temperature between 1 degree and 30 degrees Celsius. It should also be used within 36 months from the manufacturing date to maintain effectiveness.

Appearance

<Domestic> Green rectangular tablet, <Export> Green round tablet

Package unit

30 tablets/bottle, 100 tablets/bottle, 500 tablets/bottle