Clarithromycin 500 mg Tablets

Adult dose

○ Adults: The usual dose is clarithromycin 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medication to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medication twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medication 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in certain patients. For example, patients who are allergic to any of the ingredients contained in this medication or have shown hypersensitivity to similar antibiotics should not be administered this drug. Additionally, it is safest not to use this drug in patients with arrhythmias, severe liver impairment, significantly reduced renal function, pregnant women, or breastfeeding women. This medication may cause serious side effects such as arrhythmias when taken along with certain other medications, so patients taking such medications must consult their doctor. Patients with impaired liver and renal function, those with heart diseases, the elderly, etc., should exercise caution when using this medication. When taking other antibiotics concurrently, drug-drug interactions may occur; therefore, all medications being taken should be disclosed to healthcare providers. While taking this medication, rare occurrences of severe allergic reactions, skin rashes, gastrointestinal disturbances, liver function abnormality, renal function abnormality, central nervous system abnormal symptoms may appear, and if any abnormal symptoms occur, healthcare providers should be notified immediately. To prevent the occurrence of resistant bacteria, it is important to take the medication for the required duration and not to stop its use arbitrarily even if symptoms improve. After using antibiotics, gastrointestinal symptoms such as diarrhea may appear, and if they persist, healthcare providers should be consulted. Pregnant or breastfeeding women should not take this medication, and there are age limitations for children, so caution should be exercised. Elderly patients may require dose adjustments due to decreased bodily functions which may lead to increased drug concentration. During the course of this medication, caution is needed for patients who may experience dizziness or confusion while driving or operating machinery. In the case of overdose, gastrointestinal disturbances or psychiatric symptoms may occur, and in such cases, immediate medical attention should be sought. This medication has many drug interactions, so patients should inform healthcare providers of any medications they are taking, and regular tests should be performed to monitor liver, kidney, and blood conditions. Finally, this medication should be stored away from direct sunlight and at room temperature, and refrigeration is not recommended.

Shock, anaphylactic symptoms, difficulty breathing, seizures, flushing, rash, itching, hives, skin redness, angioedema, joint swelling, drug rash, abdominal fullness, nausea, vomiting, indigestion, abdominal pain, malaise, bloating, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, tooth discoloration, pancreatitis, amylase increase, dysgeusia, appetite loss, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, anosmia, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash, jaundice, hepatocellular hepatitis, cholestatic hepatitis, elevated liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorder, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized exanthematous pustulosis, muscle spasms, musculoskeletal stiffness, myopathy, elevated serum creatinine, elevated serum urea, nephritis, venous thrombophlebitis at injection site, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication is sensitive to light and should be stored in a tightly closed container that protects it from light. Additionally, to maintain its effectiveness, it is best to store it at room temperature, specifically between 15 to 30 degrees Celsius.

Appearance

Yellow, rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle