Clarosin Tablets (Clarithromycin)

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily. For severe infections, administer 500mg (potency) per dose twice daily. The usual treatment period is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or 250mg (potency) per dose twice daily for severe infections. Do not administer this drug to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) per dose twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this drug 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and administer omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years of age and older: Same as adults. For children younger than 12 years, use clarithromycin dry syrup.

This medication should not be administered to patients with specific allergic reactions. For example, it should not be used in patients who are allergic to this medication's ingredients or related antibiotics. Additionally, it should be avoided in patients with certain heart conditions or severely impaired liver or kidney function. It is also safer not to use this medication in women who are pregnant or breastfeeding. This medication can interact with various other drugs, so it is essential to consult a doctor or pharmacist if you are taking any other medications. Caution is particularly needed when taken with heart-related medications, certain antibiotics, anticoagulants, and hypoglycemic agents. When using this medication, be aware that allergic reactions or serious side effects may occur, and immediately inform healthcare providers if any unusual symptoms appear. Long-term or high-dose use may lead to side effects such as hearing problems or liver function abnormalities; therefore, regular assessments are necessary. Elderly patients or those with impaired liver or kidney function may require dose adjustments and should discuss this with their healthcare providers. It is crucial to adhere precisely to the prescribed duration and dosage to prevent resistance in the infectious bacteria. Additionally, if persistent diarrhea occurs during this medication, alert healthcare providers immediately due to the potential for serious complications like gastroenteritis. Finally, be cautious, as symptoms like dizziness or confusion may occur while driving or operating machinery.

Shock, anaphylactic symptoms, dyspnea, convulsions, erythema, rash, pruritus, urticaria, skin erythema, angioedema, joint swelling, drug eruption, abdominal distension, nausea, vomiting, indigestion, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, epigastric pain, dry mouth, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, discoloration of stool, membrane colitis, hemorrhagic colitis, fever, cough, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, elevated total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste disorder, hearing loss, paresthesia, articular pain, myalgia, olfactory disturbance, hearing impairment, cardiac arrest, atrial fibrillation, ECG QT prolongation, ectopic beats, palpitations, vasodilation, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, acute generalized exanthematous pustulosis (AGEP), muscle cramps, musculoskeletal rigidity, myopathy, nephritis, injection site thrombophlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, increased serum lactic dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urinary discoloration, changes in mental status, obsessive behavior, hypokalemia, hypoxemia

This medication should be stored in a tightly closed container that is free from moisture and well-ventilated. It is best stored in a temperature range of 1 to 30 degrees Celsius, avoiding direct sunlight.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle