Retos Tablets (Clarithromycin)

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for a further 14 days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This drug should not be administered to certain patients. First, patients who are allergic to any of the ingredients in this drug or have had hypersensitivity reactions to similar classes of antibiotics should not use it. Additionally, patients with specific heart diseases or severely impaired liver and kidney function may be at risk when taking this drug. Especially, women who are pregnant or breastfeeding should not take this drug, and caution is needed for patients with central nervous system infections. This drug can cause serious side effects when taken with several other medications, so if there are currently any other medications being taken, it is essential to consult with a doctor or pharmacist. During the course of taking this drug, various side effects such as allergic reactions, gastrointestinal problems, neurological abnormalities, and skin rashes may occur, so any unusual symptoms should be reported to healthcare professionals immediately. If symptoms such as irregular heartbeat or shortness of breath occur, administration should be stopped immediately, and treatment should be sought. This drug can affect liver and kidney function, so regular blood tests and health checks are necessary. Moreover, prolonged or repeated use of this drug may lead to drug resistance, so the recommended duration and dosage by the physician must be strictly followed. Caution is needed while driving or operating machinery during treatment, so it is advisable to be cautious when engaging in such activities. In case of overdose, symptoms such as gastrointestinal disorders or neurological abnormalities may arise, thus strict adherence to the prescribed dosage must be observed. When storing, it is best to keep it in a sealed container protecting it from light and at room temperature between 15°C and 30°C. This helps maintain the drug's effectiveness.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, hives, mild skin erythema, angioedema, joint swelling, drug eruption, abdominal distention, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, chest X-ray abnormalities, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug eruption with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, kidney failure, rhabdomyolysis, stomatitis, oral mucositis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, gustatory impairment, auditory loss, paresthesia, arthralgia, myalgia, olfactory disturbance, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute generalized exanthematous pustulosis, angioedema, decreased appetite, hypoglycemia, insomnia, neuroexcitability, noise sensitivity, confusion, abnormal dreams, mania, vestibular vertigo, hearing impairment, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, increased alanine aminotransferase, increased aspartate aminotransferase, increased gamma-glutamyl transferase, hepatocellular jaundice, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schönlein purpura, muscle spasms, musculoskeletal rigidity, myopathy, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This drug should be stored in a sealed container that can block light, and it is safest to keep it at room temperature between 15°C and 30°C. Storing it this way helps maintain the drug's effectiveness.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle