Glupide Tablets (Glibenclamide)

Adult dose

Dose must be adjusted individually for each patient. Swallow without chewing with more than half a cup of water. Administer orally once daily. It should be taken before breakfast or just before the first meal. 1. Monotherapy - The initial dose is 1 mg of glibenclamide once daily. - The dose may be increased by 1 mg every 1 to 2 weeks as needed. - Generally, additional effects are minimal when exceeding 4 mg, but

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or in a comatose state. Patients who are allergic to this medication or its components, or to sulfonylureas should also not use this medication. There is no experience using this medication in patients with severely impaired liver or kidney function, thus switching to insulin therapy is recommended. It should not be used in pregnant or potentially pregnant women, or breastfeeding women. Patients with severe infections, or those following surgery or severe trauma may require insulin therapy. Patients with gastrointestinal disturbances such as diarrhea or vomiting should be cautious, as these may lead to malabsorption and risk of hypoglycemia. During the first week of taking this medication, there is a high risk of hypoglycemia, so blood sugar should be closely monitored. Special attention is needed for the elderly, patients with poor nutritional status or irregular eating habits, those with mismatched exercise and food intake, changes in meal patterns, frequent alcohol consumption, those with weakened kidney or liver function, and those who overdose on this medication. This medication can cause hypoglycemia, with symptoms including headache, severe hunger, nausea, fatigue, anxiety, decreased concentration, confusion, dizziness, drowsiness, and decreased consciousness. Hypoglycemia is typically quickly alleviated by consuming sugary food or drinks. Rarely, visual disturbances, gastrointestinal issues, liver function abnormalities, blood disorders, and allergic reactions may occur, and if any abnormal symptoms arise, the patient should inform their doctor or pharmacist immediately. When taking this medication, regular meals, exercise, and weight management are crucial, and blood sugar control should be consistently monitored. If hypoglycemia occurs, sugar should be taken immediately, and the symptoms and risks of hypoglycemia should be clearly explained to the patient and their family to prepare for emergency situations. In situations of stress, surgery, or infections that make blood sugar control difficult, transitioning to insulin therapy may be considered. Pregnant or breastfeeding women should not use this medication, and women who plan to become pregnant must consult their doctor. Elderly patients may have reduced kidney function, so dosing should be adjusted cautiously. Overdosing on this medication can lead to severe hypoglycemia, so immediate medical treatment is necessary, and blood sugar should be monitored closely for 24 to 48 hours. The safety and efficacy of this medication have not been established in children, so it should not be used in children. When storing this medication, keep it out of the reach of children, and store it in the original container. There may be interactions when taken with other medications, so all medications the patient is currently taking should be disclosed to the doctor or pharmacist.

Serious side effects

Hives, severe swelling (edema), itching, rash, difficulty breathing, hypotension, shock, anaphylaxis, angioedema, Stevens-Johnson syndrome, abnormal liver function (including jaundice), hepatitis, cholestasis, coma due to severe hypoglycemia, loss of consciousness, convulsions, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, thrombocytopenic purpura, severe.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• reduced agility or activity

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. It is recommended to maintain the storage temperature between 1 and 30 degrees Celsius. This will help preserve the medication's efficacy and safety for a long time.

Appearance

Green rectangular tablet

Package unit

30 tablets/bottle, 100 tablets/bottle