Kingsep Tablet (Cefprozil Hydrate)

Adult dose

○ Adults (13 years and older) 1) For pharyngitis and tonsillitis among upper respiratory tract infections, administer cefprozil 500mg (potency) per dose every 24 hours; for acute sinusitis, administer 250mg (potency) or 500mg (potency) every 12 hours (dose increases are needed for moderate or more severe infections). 2) For bacterial secondary infection of acute bronchitis or bacterial exacerbation of chronic bronchitis among lower respiratory tract infections, administer 500mg (potency) of this medicine per dose every 12 hours. 3) For uncomplicated skin and soft tissue infections, administer 250mg (potency) of this medicine per dose every 12 hours [or 500mg (potency) every 24 hours], or 500mg (potency) every 12 hours according to symptoms. 4) For uncomplicated urinary tract infections, administer 500mg (potency) of this medicine every 24 hours. <Duration of administration> Usually administer for about 10 days; however, for pharyngitis/tonsillitis caused by Streptococcus pyogenes (group A beta-hemolytic), administer for 10 days or longer. Also, for uncomplicated cystitis, administer for about 7 days. ○ Patients with renal impairment 1) For creatinine clearance of 30～120mL/min, administer according to the standard dosage regimen above. 2) For creatinine clearance of 29mL/min or less, administer 50% of the standard dose at the standard dosing interval. However, some of this medicine is removed by hemodialysis, so administer it after hemodialysis is completed. Once reconstituted, store in a refrigerator and use within 14 days (syrup only).

Child dose

○ Children (2～12 years), upper respiratory tract infections, pharyngitis and tonsillitis: Administer 7.5mg (potency)/Kg per dose every 12 hours. ○ Children (2～12 years), uncomplicated skin and soft tissue infections: Administer 20mg (potency)/Kg per dose every 24 hours. ○ Infants and children (6 months～12 years), upper respiratory tract infection, otitis media: Administer 15mg/Kg every 12 hours. ○ Infants and children (6 months～12 years), acute sinusitis: Administer 7.5mg/Kg every 12 hours. ○ Infants and children (6 months～12 years), acute sinusitis (moderate or more severe infection requiring a dose increase): Administer 15mg/Kg every 12 hours.

This medication is a cephalosporin antibiotic and should not be administered to certain patients. Patients who have had an allergy to cephalosporin antibiotics should avoid using this medication. Patients with allergies to penicillin or other medications should also use this medication with caution, as allergic reactions may cross-react among similar classes of drugs. Severely ill patients or those with suspected kidney function issues need careful observation and appropriate testing when using this medication. Patients with impaired kidney function may require a dose reduction to minimize side effects. Individuals with a history of gastrointestinal diseases, especially colitis, should also use this medication cautiously. Additionally, caution is needed in patients allergic to specific colorants included in this medication. Common gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal pain may occur with this medication. Adverse reactions such as liver function abnormalities, skin rashes, and urticaria may also arise, so if these symptoms occur, immediate consultation with a healthcare professional is necessary. Rare reports of central nervous system symptoms such as dizziness, headaches, and drowsiness have been noted, and seizures may occur, so patients with reduced kidney function should be particularly cautious. When used with other antibiotics or diuretics, there may be an increased risk of nephrotoxicity, necessitating careful monitoring during concurrent use. Use during pregnancy should be limited to essential cases only, and nursing mothers should administer with caution, as this medication is excreted in small amounts in breast milk. It is advisable not to use this medication in infants less than 6 months of age, as safety and efficacy have not been established. Elderly patients may require dosage adjustments due to potential renal function decline, and clinical tests such as blood tests should be conducted during treatment to monitor for adverse reactions. Since this medication is excreted through the kidneys, in cases of overdose, it may be possible to remove the drug through hemodialysis in patients with kidney impairment. Finally, it is important to conduct sensitivity testing to prevent the emergence of resistant bacteria and only use the medication for the minimally necessary duration.

• Diarrhea
• nausea
• vomiting
• abdominal pain
• elevated AST
• elevated ALT
• elevated ALP
• elevated bilirubin levels
• rash
• urticaria

This medication is sensitive to light and should be stored in a container that does not allow light to enter. Additionally, when storing the medication, it is crucial to maintain a temperature between 1 degree and 30 degrees Celsius at room temperature. This way, the effectiveness of the medication can be preserved for a longer period.

Appearance

Pale yellow, rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle