Cephre Capsule 250 mg (Cefaclor Hydrate)

Adult dose

As cefaclor hydrate, administer 250 mg (potency) orally every 8 hours. For severe infections (such as pneumonia) and infections with low susceptibility, dosing may be doubled. In the case of acute gonococcal urethritis, this medication in a single dose of 3 g should be given in combination with 1 g of probenecid.

Child dose

Administer 20 mg/kg (potency) divided every 8 hours. In cases of severe infections, otitis media, and infections with low susceptibility, 40 mg/kg (potency) may be administered daily, with a maximum dose of

This medication works by binding to specific proteins and inhibiting bacterial cell wall synthesis, thereby killing bacteria. Patients who have previously experienced severe allergic reactions or shock from this medication or similar antibiotics should not be administered this drug. Additionally, patients with a history of allergy to penicillin antibiotics or a family history of asthma, rashes, or hives should be cautious when using this medication. Patients with severely impaired kidney function, those unable to take the medication orally, elderly patients, and patients in poor general condition should be closely monitored during treatment as they may show signs of vitamin K deficiency. Patients with a history of gastrointestinal diseases, particularly colitis, should also be administered with caution. Although rare, this medication may cause serious allergic reactions or skin conditions, blood abnormalities, liver and kidney dysfunction, gastrointestinal issues, respiratory disorders, and central nervous system disturbances. If any unusual symptoms occur, the use of this drug should be stopped immediately and appropriate treatment should be sought. To prevent the emergence of antibiotic-resistant bacteria, it is essential to check the susceptibility of the infecting bacteria and use this medication only for the minimum required period. When using this medication, it is essential to conduct a thorough medical history to check for any prior allergic reactions and consider the potential for co-infection with resistant bacteria when selecting an appropriate treatment method. This drug may interact with other medications, particularly probenecid, nephrotoxic medications, anticoagulants, oral contraceptives, and certain antibiotics, so caution is advised. Women who are pregnant or may become pregnant should use this medication only when the benefits outweigh the risks, and nursing mothers should also use it with caution. Safety for newborns, especially infants under one month old, has not been established, so caution should be exercised in its use. Elderly patients may have an increased risk of bleeding due to decreased bodily functions and vitamin K deficiency, so dosage and administration interval should be adjusted and their conditions should be closely monitored. This medication may affect the results of urine or blood tests, so caution should be exercised in interpreting test results.

Serious side effects

Shock, anaphylactic symptoms (generalized flushing, swelling, difficulty breathing, vascular edema, sensory disturbances, fainting, hypertension, vasodilation), hives, Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, pancytopenia, aplastic anemia, hemolytic anemia, liver abnormalities (temporary hepatitis, jaundice), acute renal failure, kidney abnormalities (reversible interstitial nephritis, increased BUN, increased serum creatinine), severe colitis (pseudomembranous colitis), seizures

Mild side effects

Rash, itching, fever, lymphadenopathy, joint pain, serum sickness-like reactions, hematological adverse reactions (agranulocytosis, granulocytopenia, anemia, etc.), temporary hepatitis, increased AST, ALT, ALP, nausea, vomiting, diarrhea, abdominal pain, discomfort in the stomach area, heartburn, loss of appetite, anxiety, agitation, muscle tension, irritability, insomnia, confusion, dizziness, hallucinations, drowsiness, stomatitis, candidiasis, vitamin K deficiency symptoms, vitamin

This medication should be stored in a sealed container to prevent exposure to air or humidity and kept at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness safely.

Appearance

A hard capsule with a purple upper half and a white lower half containing a pale yellow powder

Package unit

30 capsules/bottle, 300 capsules/bottle