Daewoong Famciclovir Tablet 250 mg (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg orally 3 times daily for 7 days. It is advisable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer this drug 250 mg orally 3 times daily for 5 days. It is advisable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer this drug 125 mg orally twice daily for 5 days. It is advisable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this drug 250 mg orally twice daily. Temporarily discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Because creatinine clearance of this drug is reduced in patients with renal impairment, dose adjustment should be made with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formula. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients undergoing hemodialysis, administration every 48 hours is advisable, taking the dialysis interval into account. Because 4 hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%, administer this drug immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This drug should not be used by anyone who is allergic to this drug or its ingredients. Additionally, since it contains lactose, individuals with a genetic inability to digest lactose should not take this medication. Patients with renal dysfunction must be particularly careful when using this drug, and dosage adjustments may be necessary. Headaches, dizziness, nausea, vomiting, skin rash, and itching may occur during treatment, so consult a doctor if any abnormal symptoms arise. This drug cannot completely cure genital herpes, so it is important to avoid sexual contact and maintain safe sexual practices during treatment. If dizziness or drowsiness occurs, avoid driving or operating machinery. Patients with severely impaired liver function should be cautious as the effectiveness of this drug may decrease. There may be interactions when taking this drug with other medications, so inform your doctor or pharmacist if you are taking other drugs. Women who are pregnant or breastfeeding should carefully consider the benefits and risks of using this drug, and women of childbearing potential should also be cautious. Children under 18 years old should preferably avoid using this drug as safety and efficacy are not established. Elderly patients may require dosage adjustments based on renal function. In case of overdose, contact a medical institution immediately for appropriate treatment, and if necessary, the drug can be removed via hemodialysis. Store this drug in a dry place below 30 degrees Celsius, away from children, and it is safer to keep it in its original container.

• headache
• nausea
• thrombocytopenia
• leukopenia and neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations
• vomiting

Store this drug in a tightly sealed container to protect it from air and moisture. Additionally, it is best to keep it in a dry place below 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

21 tablets (7 tablets/PTP) x 3