Cefprozil Dry Syrup 125 mg/5 mL (Cefprozil Monohydrate)

Adult dose

○ Adults (13 years of age and older) 1) For pharyngitis and tonsillitis, which are upper respiratory tract infections, administer 500mg (potency) of cefprozil per dose every 24 hours. For acute sinusitis, administer 250mg (potency) or 500mg (potency) every 12 hours (dose escalation is necessary for moderate or more severe infections). 2) For bacterial superinfection in acute bronchitis or bacterial exacerbation of chronic bronchitis, which are lower respiratory tract infections, administer 500mg (potency) of this medicine per dose every 12 hours. 3) For uncomplicated skin and soft tissue infections, administer 250mg (potency) of this medicine per dose every 12 hours [or 500mg (potency) every 24 hours], or administer 500mg (potency) every 12 hours depending on symptoms. 4) For uncomplicated urinary tract infections, administer 500mg (potency) of this medicine every 24 hours. <Duration of administration> Administration is usually for about 10 days; however, for pharyngitis/tonsillitis caused by Streptococcus pyogenes (Group A beta-hemolytic), administer for 10 days or longer. For uncomplicated cystitis, administer for about 7 days. ○ Patients with renal impairment 1) For creatinine clearance of 30～120mL/min, administer according to the standard dosage and administration described above. 2) For creatinine clearance of 29mL/min or less, administer 50% of the standard dose at the standard dosing interval. However, some of this medicine is removed by hemodialysis, so administer it after hemodialysis is completed. After reconstitution, store refrigerated and use within 14 days (syrup only).

Child dose

○ Children (2～12 years) For pharyngitis and tonsillitis, which are upper respiratory tract infections, administer 7.5mg (potency) per Kg of body weight per dose every 12 hours. ○ Children (2～12 years) For uncomplicated skin and soft tissue infections, administer 20mg (potency) per Kg of body weight per dose every 24 hours. ○ Infants and children (6 months～12 years) For otitis media, which is an upper respiratory tract infection, administer 15mg per Kg of body weight every 12 hours. ○ Infants and children (6 months～12 years) For acute sinusitis, administer 7.5mg per Kg of body weight every 12 hours. ○ Infants and children (6 months～12 years) For moderate or more severe infections requiring dose escalation, administer 15mg per Kg of body weight every 12 hours.

This medication is a cephalosporin antibiotic and should not be used in certain patients. For example, individuals who have had an allergic reaction to this medication or those with a genetic disorder that prevents lactose digestion should not be administered this drug. Additionally, patients with allergies to penicillin or other medications should use this medicine with caution. Patients with impaired kidney function or gastrointestinal disorders should be carefully monitored when using this medication. Taking this medication may result in gastrointestinal side effects such as diarrhea, nausea, vomiting, and abdominal pain, and liver function tests may show elevated levels. Allergic reactions such as skin rashes or hives may occur rarely, so caution is necessary. This drug may affect the central nervous system, leading to dizziness, headaches, or insomnia, and patients with impaired kidney function may be at risk of seizures; therefore, it is important to discontinue use immediately if any unusual symptoms arise. Prolonged use of this medication can lead to the development of resistant bacteria, so it should only be taken for the minimum period as directed by a physician, with close monitoring of the infection status during treatment. If an allergic reaction occurs, discontinue use immediately and seek necessary emergency treatment. Furthermore, if severe diarrhea develops while taking this medication, proper treatment should be sought considering the possibility of pseudomembranous colitis. When used with other antibiotics or diuretics, there may be an increased risk of renal toxicity, so caution is needed. Pregnant or breastfeeding women should only use this medication if absolutely necessary, and it should be used with caution in infants or neonates where safety hasn't been thoroughly established. Elderly patients may require dose adjustment due to the potential for decreased kidney function. This medication is excreted through the kidneys, so in cases of overdose in patients with impaired kidney function, it can be removed via hemodialysis. Finally, this medication is not known to pose a risk of carcinogenicity or mutagenicity and is not known to affect reproductive function.

• Diarrhea
• nausea
• vomiting
• abdominal pain
• elevated AST
• elevated ALT
• elevated ALP
• increased bilirubin level
• cholestatic jaundice
• rash

This medicine should be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Pink powder syrup

Package unit

60 mL/bottle, 150 mL/bottle