Zeclara Tablets (Clarithromycin)

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this drug to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this drug twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this drug 3 times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

○ Children 12 years of age and older: Same as adults. ○ Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be administered to patients with allergies to specific components. In particular, patients who have had hypersensitivity reactions to antibiotics in the same class should avoid its use. Additionally, it should be avoided in patients with severe heart diseases or severely impaired liver or kidney function. It is also not recommended for pregnant or breastfeeding women. This drug has a high potential for drug interactions, so if you are taking other medications, be sure to consult with your doctor or pharmacist. Various side effects, including allergic reactions, gastrointestinal issues, neurological abnormalities, skin rashes, etc., may occur, so if any unusual symptoms arise, you should notify your healthcare provider immediately. Careful monitoring is required, especially due to the possibility of cardiac arrhythmias or severe allergic reactions. Elderly patients or those with weakened liver or kidney functions may require dosage adjustments, so follow your healthcare provider's instructions. Long-term use can lead to the emergence of resistant bacteria, so it is important to take it only for the necessary duration. This medication contains lactose, so patients with lactose intolerance should exercise caution. Lastly, dizziness or confusion may occur when driving or operating machinery, so caution is required.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug eruption, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, cramp-like upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, abdominal pain, frequent diarrhea, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsion, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, elevated total bilirubin, anorexia, dark urine, pruritus, abdominal tenderness, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, increased CPK, elevated serum myoglobin, increased urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute generalized exanthematous pustulosis, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, vascular edema, anorexia, decreased appetite, hypoglycemia, insomnia, anxiety, nervous hypersensitivity, auditory distortion, psychotic disorder, confusion, depersonalization, depression, disorientation, hallucination, abnormal dreams, mania, dysgeusia, headache, loss of consciousness, movement disorders, non-vestibular dizziness, drowsiness, tremors, convulsions, loss of taste, altered olfaction, loss of smell, vestibular dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, ECG QT prolongation, premature ectopic contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, diarrhea, vomiting, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distention, constipation, thirst, belching, abdominal bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, bile stasis, hepatitis, increased alanine aminotransferase, increased aspartate aminotransferase, increased gamma-glutamyl transferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, itching, urticaria, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal rigidity, myalgia, rhabdomyolysis, myopathy, elevated serum creatinine, increased blood urea, renal failure, nephritis, phlebitis at the injection site, pain at the injection site, inflammation at the injection site, fatigue, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication should be stored in a tightly sealed container that blocks light and at room temperature between 15 to 30 degrees Celsius. Proper storage helps maintain the drug's efficacy.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle