Yuyu Mycobutin Capsule (Rifabutine)

Adult dose

1. Adults 1) Suppression of MAC infection in immunocompromised patients with a CD4 lymphocyte count of 200cells/μL or less: Administer rifabutin 300mg (potency) once daily. In patients with nausea, vomiting, or gastrointestinal disturbances, taking 150mg (potency) per dose twice daily with food is effective. 2) Localized or systemic infections caused by nontuberculous mycobacteria: Administer 450～600mg (potency) per day in combination therapy. Continue treatment for up to 6 months after a negative result. 3) Pulmonary tuberculosis: Administer 150～450mg (potency) per day for at least 6 months. In general, this medicine should be administered in combination with other antimycobacterial medicines that do not belong to the rifamycin class. 2. Patients with severe renal impairment (creatinine clearance less than 30mL/min): Reduce the dose by 1/2.

This medication belongs to the rifamycin class, and should not be administered to certain patients. For example, patients who have had hypersensitivity reactions to this drug or rifamycin derivatives, pregnant or nursing women, and children due to insufficient clinical experience should avoid using this medication. It should be administered cautiously in patients with severe liver or very poor kidney function. When using this medicine, various side effects may occur. The most common side effects include insomnia, taste disturbances, gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal bloating, etc.), liver function abnormalities, blood cell deficiencies, discoloration of urine, skin rashes, allergic reactions, arthralgia, and myalgia, among others. In rare cases, serious side effects such as flu-like symptoms, hepatitis, hemolytic anemia, and breathing difficulties may occur, so it is important to consult a physician immediately if any unusual symptoms appear. Prolonged or repeated use of this drug may lead to the development of resistant bacteria, so it is crucial to check the susceptibility of the infectious bacteria and use it for only the necessary minimum duration. Regular blood tests and liver function tests should be conducted, and prompt notification to the doctor is necessary if any symptoms of infection or new symptoms occur. Be aware that body fluids or secretions and skin may turn brown when using this medication, and individuals wearing soft contact lenses should be cautious as the lenses may become discolored. This drug may interact with various medications, particularly activating enzymes that are involved in drug metabolism in the liver, reducing the effects of other drugs. Particularly, when taken alongside oral contraceptives, the contraceptive effect may be diminished, so it is advisable to use non-hormonal contraceptive methods. Additionally, dosage adjustments may be required when used with certain antiviral drugs, anticoagulants, analgesics, etc. There is insufficient safety data for pregnant or nursing women and children, and it is advisable not to use this drug in these populations. Lastly, if an overdose occurs, serious side effects such as uveitis may manifest, so appropriate treatment should be sought immediately if suspected.

Insomnia, taste disturbance, gastrointestinal hypersensitivity, nausea, vomiting, increased liver enzymes, jaundice, loss of appetite, diarrhea, indigestion, belching, abdominal bloating, leukopenia, thrombocytopenia, anemia, discoloration of urine, rash, fever, eosinophilia, bronchospasm, shock, arthralgia, myalgia, abdominal pain, weakness, chest pain, heat, headache, pain, flu-like syndrome, hepatitis, hemolysis, myositis, chest tightness or pain accompanied by dyspnea, skin discoloration, seizures, sensory disturbance, aphasia, confusion, non-specific T-wave changes on ECG, uveitis

This drug should be stored in a special container that does not allow light in, at room temperature between 15 to 25 degrees Celsius. Proper storage will help maintain the drug's efficacy and ensure its safe use.

Appearance

A hard capsule filled with reddish-brown powder

Package unit

30 tablets (10 tablets/PTPX3)