Hericlone Dry Syrup 125mg/5mL (Clarithromycin)

Adult dose

For patients with renal impairment and a creatinine clearance of 30mL/min/1.73m2 or less, the dose should be reduced by half. Do not administer to these patients for more than 14 days.

Child dose

The usual pediatric dose is 7.5mg per Kg of body weight every 12 hours (15mg/Kg/day). The usual duration of treatment is 5～10 days. Since food does not affect the bioavailability of this medication, it may be administered regardless of meals. It may be taken with food or milk. Mycobacterial infections: Administer 7.5～15mg per Kg of body weight every 12 hours (15～30mg/Kg/day). Do not exceed 500mg (potency) per dose or twice daily, as clarithromycin (potency).

This medication should not be used by individuals allergic to certain additives. Individuals who have had hypersensitivity reactions to clarithromycin or similar class antibiotics should also refrain from taking this medication. It may be dangerous when taken with certain medications that can affect heart rhythm; therefore, patients currently taking such medications should not use it. Patients with congenital or previously diagnosed cardiac arrhythmias or severe liver dysfunction should also avoid this drug. Women who are pregnant or breastfeeding should not take this medication for safety reasons. Caution should be exercised when used in patients with central nervous system infections or those currently on certain other medications. Patients with liver or kidney dysfunction may require dosage adjustment; therefore, caution is advised. Elderly patients and those with heart disease should also be careful while using this medication. Rarely, allergic reactions, gastrointestinal disturbances, liver function abnormalities, kidney problems, skin rashes, symptoms related to the central nervous system may occur during the medication period; if symptoms arise, consult healthcare personnel immediately. Additionally, this medication may interact with several other medications, so it is essential to inform healthcare providers of any other medications being taken. In cases of overdose, gastrointestinal disturbances or psychiatric symptoms may occur; therefore, strict adherence to the prescribed dosage is necessary. This medication should be used for the minimum necessary duration as directed by a physician to prevent the development of resistant bacteria. Lastly, this drug should not be refrigerated during storage and should be kept in a cool, dark place.

Shock, anaphylaxis symptoms, shortness of breath, seizures, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, indigestion, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, decreased appetite, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, abdominal pain, frequent diarrhea, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltrate, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, decreased appetite, jaundice, dark urine, itching, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, fatigue, elevated CPK, increased myoglobin in blood, increased myoglobin in urine, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, lethargy, headache, taste distortion, hearing loss, parathesia, arthralgia, myalgia, olfactory disturbance, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, purpuric rash, acute generalized exanthematous pustulosis, soft tissue infection, candidiasis, gastroenteritis, infection, vaginal infection, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, hypersensitivity, decreased appetite, insomnia, anxiety, nervousness, noise sensitivity, psychotic disorder, confusional state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, headache, loss of consciousness, movement disorders, non-vertiginous dizziness, drowsiness, tremor, vertiginous dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, ECG QT prolongation, ectopic beats, palpitations, vasodilation, asthma, nasal hemorrhage, pulmonary embolism, diarrhea, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, bile duct obstruction, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, liver failure, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, muscle spasm, musculoskeletal stiffness, myopathy, elevated blood urea, venous thrombophlebitis at injection site, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin/globulin ratio, elevated alkaline phosphatase in blood, elevated lactate dehydrogenase in blood, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication should be kept in a tightly sealed container to avoid exposure to air and moisture. It is best to maintain a storage temperature between 1°C and 30°C.

Appearance

A white to off-white granular powder dry syrup that is to be dissolved before use.

Package unit

100 milliliters/bottle