Esmorphin Tablet (Morphine Sulfate Hydrate)

Adult dose

(15 mg tablets) The usual adult dose is 15–30 mg of morphine sulfate hydrate orally every 4 hours; adjust as appropriate according to the physician's prescription. To relieve suffering in terminal illness, regular administration every 4 hours at the minimum dose that provides analgesia with this medicine is recommended.

This medication is a powerful analgesic that acts on the central nervous system and can lead to severe respiratory depression or coma if taken with narcotics, benzodiazepine drugs, or alcohol; therefore, caution is necessary when combining. There are patients who should not receive this medication, including those with hypersensitivity to the drug, patients with severe respiratory depression, those undergoing an asthma attack, or patients in a state of severe central nervous system depression. Furthermore, patients with heart failure due to chronic lung disease, patients with arrhythmia, those with elevated intracranial pressure, and patients with acute alcohol intoxication are also prohibited from using this medication. Patients with severely impaired liver or kidney function, as well as those with genetic metabolic disorders such as lactose intolerance should not use this drug. Patients with cardiac disease or respiratory depression, metabolic acidosis, and hypothyroidism should use this medication with caution, and especially in elderly or frail patients, neonates, and infants, treatment should start at a low dose and their condition should be closely monitored. This medication may cause tolerance and dependence with long-term use, so the duration of treatment and dosage should be minimized, and if withdrawal symptoms occur, the dosage should be gradually reduced. Drowsiness or dizziness may occur during administration, hence driving or operating dangerous machinery should be avoided. This medication may place a burden on the liver or pancreas, so caution is necessary in cases of abnormal liver function or symptoms of pancreatitis. Additionally, this drug interacts with many other medications, so when combined with other analgesics, sedatives, antidepressants, anticoagulants, etc., dosage adjustments and close monitoring are required. Women who are pregnant or may become pregnant should be cautious about taking this medication, and it should not be used during delivery due to the risk of respiratory depression in the newborn. Breastfeeding women should discontinue nursing as this medication is passed into breast milk. In case of overdose, severe respiratory depression, loss of consciousness, hypotension, etc., may occur and immediate emergency care is necessary, including administration of opioid antagonists and close monitoring of breathing and circulation.

Yawning, sneezing, tearing, sweating, nausea, vomiting, diarrhea, abdominal pain, pupil dilation, headache, insomnia, anxiety, hallucination, convulsions, tremors, pain in muscles and joints throughout the body, shortness of breath, palpitations, difficulty breathing, slow breathing, irregular breathing, apnea, confusion, forgetfulness, head injury, increased intracranial pressure, low blood pressure, shock, atelectasis, bronchospasm, laryngeal edema, liver dysfunction, feeling of emptiness in the head, sedation, dizziness, sweating, itching, skin rash, hives, hemorrhagic hives, swelling, palpitations, bradycardia, fainting, blood pressure fluctuations, arrhythmia, facial flushing, weakness, headache, insomnia, loss of directional sense, drowsiness, altered consciousness, anxiety, excitement, hallucinations, malaise, dysentery pain, hyperalgesia, hyperhidrosis, constipation, abdominal bloating, abdominal pain, gastric discomfort, thirst, loss of appetite, biliary spasm, taste disorder, dry mouth, pancreatitis, sphincter of Oddi spasm, urinary retention, antidiuretic effect, decreased libido, sexual dysfunction, skeletal muscle rigidity, anemia, thrombocytopenia, swelling, weight loss, acute generalized rash with pustules, central sleep apnea syndrome, fatigue, visual disturbances, eye pain, amblyopia, coma, stupor, skeletal muscle relaxation, cold skin, miosis, bradycardia, hypotension, apnea, cardiovascular collapse, cardiac arrest, aspiration pneumonia

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature. This helps to preserve the efficacy and safety of the medication for a long time.

Appearance

White, round film-coated tablet

Package unit

100 tablets (10 tablets/PTP packaging x 10)