Clarithromycin Dry Syrup 125mg/5mL (Clarithromycin)

Adult dose

In patients with renal impairment whose creatinine clearance is 30mL/min/1.73m2 or less, the dose should be reduced by half. Do not administer this medicine to these patients for more than 14 days. This medicine is not affected by food in terms of bioavailability, so it may be taken regardless of meals. It may be taken with food or milk.

Child dose

Usually, administer 7.5 mg per Kg of body weight in children (approximately 0.3 mL/Kg of the reconstituted preparation) every 12 hours (15 mg/Kg/day). The treatment period is usually 5～10 days. ○ Mycobacterial infections Administer 7.5～15 mg per Kg of body weight in children (approximately 0.3 mL-0.6 mL/Kg of the reconstituted preparation) every 12 hours (15～30 mg/Kg/day). Do not exceed 500mg (as clarithromycin potency) per dose or 2 doses per day.

This medication should not be used by individuals who are allergic to specific ingredients. Those who have had allergies to similar antibiotics should also avoid taking it. It may be risky for patients taking certain medications that can affect heart rhythm. Administration is contraindicated for patients with severe heart rhythm abnormalities or severe impaired liver function. It is safest for pregnant or breastfeeding women to avoid this medication. Patients with weak liver or kidney function should adjust the dosage and administration intervals of this medication. Elderly patients or those with heart disease should use this medication with caution. When used in conjunction with other antibiotics, be careful of resistant bacteria development and drug interactions. This medication may cause various side effects including gastrointestinal disturbances, allergic reactions, and liver function abnormalities, so consult a healthcare provider immediately if any abnormal symptoms appear. If severe allergic reactions or skin reactions occur, discontinue the use of the medication immediately. If persistent diarrhea or abdominal pain appears during use, caution is required due to the possibility of pseudomembranous colitis. When used together with other drugs, there may be changes in drug concentrations and risks of side effects, so consult a physician before combining medications. Women who are pregnant or potentially pregnant should not use this medication, and those who are breastfeeding should consider avoiding administration or stopping breastfeeding. Special evaluation and dosage adjustments are necessary for children or the elderly before administration. Overdose may lead to gastrointestinal symptoms or central nervous system abnormalities, and immediate medical attention is required.

Shock, anaphylactic symptoms, respiratory distress, seizures, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disorders, anorexia, constipation, stool discoloration, necrotizing colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremor, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de Pointes, lethargy, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle spasms, musculoskeletal rigidity, myopathy, elevated serum creatinine, elevated blood urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated blood lactate dehydrogenase, increased INR, prolonged prothrombin time, urine color abnormality

This medication should be stored in a tightly sealed container to prevent air or moisture ingress and should be kept at room temperature between 1°C and 30°C. Proper storage conditions help maintain the effectiveness and safety of the medication.

Appearance

White to pale white granular powder

Package unit

1 bottle (100mL) / box