Gluriad Tablet 500/2.5 mg

Adult dose

The usual starting dose is 1 tablet of Metformin Hydrochloride/Glyburide 500/2.5 mg once a day. In patients receiving combined therapy of Metformin Hydrochloride and Glyburide, 2 tablets are administered daily with meals. The dose may be increased by 1 tablet every 1-2 weeks based on the patient's blood sugar levels, with a maximum dose of Metformin Hydrochloride/Glyburide 500/5 mg being administered up to 4 tablets daily.

This medication can cause severe lactic acidosis and hypoglycemia; if such symptoms occur, immediate medical attention is required. Patients with cardiovascular disease should be particularly cautious, as this medication may increase the risk of cardiovascular problems. Patients with severely impaired kidney function, heart failure, or those who have had a recent myocardial infarction should not use this medication. Patients scheduled for examinations using radiological iodinated contrast media should discontinue this medication 48 hours prior to the examination and only resume after normal kidney function is confirmed. This medication should not be administered to individuals with an allergic reaction to it, Type 1 diabetes, diabetic ketoacidosis, or pre-coma. Patients with severe infections or traumatic systemic disorders should temporarily discontinue this medication, and it should also be stopped for a certain period before and after surgeries. Caution is needed when using this medication in patients with poor nutritional status, liver dysfunction, lung function impairment, or excessive alcohol intake. It is advisable for pregnant or potentially pregnant women and nursing mothers to avoid using this medication. This medication can induce hypoglycemic symptoms, so it should be taken with regular meals, and appropriate measures should be taken immediately if hypoglycemic symptoms occur. Additionally, this medication can cause gastrointestinal disturbances, but symptoms usually resolve over time. Regular testing of liver function, kidney function, and blood tests should be performed to monitor for abnormalities during treatment with this medication. It may interact with other medications, so if other drugs are being taken, the physician or pharmacist must be informed. In cases of overdose, severe hypoglycemia or lactic acidosis may occur, so immediate emergency treatment should be sought if symptoms develop. Caution should be exercised while driving or operating machinery, as hypoglycemic symptoms or blurred vision may occur. This medication should be stored out of reach of children, and transferring it to other containers should be avoided. Finally, while taking this medication, management of condition through regular meals, exercise, and periodic blood sugar and blood tests is essential.

Serious side effects

Lactic acidosis (muscle pain, fatigue, drowsiness, difficulty breathing, abdominal pain, low body temperature, low blood pressure, bradyarrhythmia), severe allergic reactions (hives, severe swelling, tightness in the chest, difficulty breathing, cold sweat, pallor), severe skin adverse reactions (severe rashes, blisters, skin peeling, pain in mucous membranes of mouth/eyes), respiratory issues (shortness of breath or difficulty breathing, asthma attacks, cough with fever alongside respiratory issues), liver abnormalities (skin or eye

Mild side effects

Gastrointestinal symptoms (upper abdominal pain, diarrhea, nausea, vomiting, abdominal pain, loss of appetite), pruritus, urticaria, maculopapular rash, allergic vasculitis, erythema multiforme, exfoliative dermatitis, photosensitivity, metallic taste, leukopenia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, pancytopenia, decreased vitamin B12, increased liver enzymes, hepatitis, hepatic porphyria, skin porphyria, serum urea

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The medication is best stored at room temperature between 1 and 30 degrees Celsius. This helps maintain the efficacy and safety of the medication.

Appearance

An oval, light orange, film-coated tablet that is convex on both sides with '2.5' engraved on one side.

Package unit

60 tablets (20 tablets/PTP)×3, 120 tablets (20 tablets/PTP)×6