Heriko Tablets 250 mg (Clarithromycin)

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal failure whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be administered to certain patients. Individuals allergic to this drug's components or similar antibiotics should not use it. Additionally, it may be dangerous when taken with drugs affecting heart rhythm, so co-administration should be avoided. It is advisable for severely liver or kidney impaired patients, pregnant or nursing women to refrain from taking this drug. This drug can rarely cause serious allergic reactions, skin rashes, gastrointestinal disturbances, respiratory problems, blood abnormalities, and neurological issues. If these symptoms occur, immediate discontinuation and medical consultation are required. This drug can impact liver and kidney functions, thus regular testing may be needed. Furthermore, since there are many drug interactions, dosage adjustments or monitoring may be necessary based on the medications taken concurrently. Especially caution is required when combined with hypoglycemic agents, cardiac-related medications, some sedatives, and anticoagulants. When used long-term or repeatedly, resistant bacteria may develop, so it should be taken only for the minimum period as directed by a doctor. Elderly individuals, children, and immunocompromised patients should use this medication with particular care, and caution should be exercised as this drug may affect driving or operating machinery. In case of overdose, gastrointestinal disturbances or psychiatric symptoms may occur, and immediate medical attention should be sought. For storage, it should be kept in an airtight container, avoiding direct sunlight and storing at room temperature without refrigeration. To use this medication safely, consult with a doctor or pharmacist and follow their instructions closely.

Shock, anaphylactic symptoms, dyspnea, seizures, redness, rash, itching, hives, erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, tremor, paresthesia, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, elevated total bilirubin, anorexia, dark-colored urine, pruritus, abdominal tenderness, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, myalgia, weakness, elevated CPK, increased serum myoglobin, increased urinary myoglobin, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, dysesthesia, arthralgia, myalgia, olfactory disturbance, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing loss, vomiting, purpuric rash, acute generalized pustular exanthem, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reactions, angioedema, anorexia, decreased appetite, hypoglycemia, insomnia, anxiety, nervousness, noise sensitivity, psychotic disorder, confusion state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, taste disturbance, headache, loss of consciousness, movement disorders, non-vestibular dizziness, drowsiness, tremor, seizures, loss of taste, hyposmia, anosmia, vestibular dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, QT-interval prolongation on ECG, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, diarrhea, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distension, constipation, thirst, belching, bloating, acute pancreatitis, tongue discoloration, dental discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, liver failure, hepatocellular jaundice, rash, sweating, blistering dermatitis, pruritus, hives, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal stiffness, rhabdomyolysis, myopathy, elevated serum creatinine, elevated blood urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin/globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine discoloration

This drug should be stored in a tightly sealed container to avoid contact with air or moisture. The storage temperature should be maintained between 1 degree and 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle