Mebutone Tablet (Nabumetone)

Adult dose

This medication is for oral use. Swallow it without chewing (tablets only). The usual dose is 1 g of nabumetone orally once daily at bedtime. If symptoms are severe or persistent, or worsen rapidly, an additional 500 mg∼1 g of this medication may be taken orally in the morning. As with many other medications, blood concentrations may be higher in elderly patients. Do not exceed a maximum daily dose of 1 g. In some cases, a dose of 500 mg may provide satisfactory symptom relief.

Child dose

Clinical data on the use of this product in children are not yet available.

People who regularly consume more than three glasses of alcohol per day should consult a doctor or pharmacist before taking this medication. Taking it with alcohol may increase the risk of gastric bleeding. This medication may increase the risk of cardiovascular disease and serious cardiovascular issues such as myocardial infarction or stroke. Those with a history of cardiovascular disease or risk factors must be particularly cautious. While taking this medication, patients should carefully monitor for any cardiovascular symptoms and immediately inform healthcare providers if any symptoms occur. This non-steroidal anti-inflammatory drug (NSAID) can cause serious gastrointestinal problems, including gastrointestinal bleeding, ulcers, and perforation. Elderly patients or those with a history of gastrointestinal diseases are at greater risk; thus, starting with the minimum dose and careful monitoring is advised. The risk of gastrointestinal bleeding may increase when combined with other medications, so it is advisable not to take it with anticoagulants, corticosteroids, or other NSAIDs. This medication should not be given to patients with peptic ulcers, severe blood disorders, severe liver impairment, renal impairment, heart failure, those with aspirin-induced asthma, women who are pregnant or may become pregnant, children under the age of 15, or patients with inflammatory bowel disease. Patients with certain health conditions such as blood disorders, liver impairment, renal impairment, heart failure, chronic respiratory conditions, allergic rhinitis, hypertension, heart failure, autoimmune diseases, elderly individuals, etc., should use this medication with caution and may require regular examinations during treatment. This medication may rarely cause severe allergic reactions or shock, so if symptoms such as difficulty breathing, hives, or facial swelling occur, treatment should be stopped immediately and medical advice sought. Gastrointestinal discomfort, abdominal pain, nausea, vomiting, diarrhea, etc., may occur, as well as alterations in liver function, decreased kidney function, skin rashes, blood disorders, cardiovascular issues, and central nervous system symptoms. Dizziness or drowsiness may occur while taking this medication, so it is advisable to avoid driving or operating dangerous machinery. This medication can interact with other NSAIDs or various medications, so if other medications are being taken, be sure to inform a doctor or pharmacist. Women who are pregnant or breastfeeding should not use this medication, especially in late pregnancy, as it may have serious effects on the fetus. In cases of overdose, symptoms may include headaches, nausea, vomiting, gastric bleeding, and coma; appropriate treatment should be sought immediately from a medical facility. This medication should be kept out of reach of children and should not be transferred to other containers for safety.

Shock, anaphylaxis-like symptoms, dyspnea, urticaria, hypotension, angioedema, facial swelling, rash, pruritus, dyspepsia, abdominal pain, gastric discomfort, epigastric pain, abdominal bloating, loss of appetite, nausea, vomiting, hematemesis, diarrhea, constipation, air retention in the gastrointestinal tract, gastritis, peptic ulcer, perforation, gastrointestinal bleeding, gastrointestinal disorders, hematochezia, melena, ulcerative colitis, onset or exacerbation of Crohn's disease, pancreatitis, stomatitis, dry mouth, dizziness, headache, confusion, fear, neuroaesthesia, hypertonia, insomnia, drowsiness, sensory abnormalities, elevated AST, elevated ALT, elevated AL-P, liver failure, hepatitis, jaundice, nephrotic syndrome, renal failure, urinary disorders, interstitial nephritis, acute tubular necrosis, papillary necrosis, elevated urinary protein, elevated BUN, increased serum creatinine, interstitial pneumonia, respiratory distress, bronchospasm, asthma, epistaxis, vascular swelling, pseudoporphyria, hair loss, polymorphic erythema, Stevens-Johnson syndrome, toxic epidermal necrolysis, sweating, photosensitivity reactions, thrombocytopenia, neutropenia, agranulocytosis, leukopenia, leukemia, aplastic anemia, hemolytic anemia, vasculitis, hypertension, heart failure, myopathy, neck stiffness, uterine bleeding, menorrhagia, tinnitus, ear disorders, abnormal vision, visual impairment, optic neuritis, edema, fatigue, asthenia, aseptic meningitis, headache, nausea, vomiting, gastrointestinal bleeding, diarrhea, disorientation, agitation, coma, dizziness, tinnitus, fainting, convulsions, acute renal failure, liver damage

This medication should be stored in a sealed container to prevent air or moisture exposure, and it is recommended to keep it at room temperature, between 1 to 30 degrees Celsius. Proper storage helps maintain the effectiveness of the medication and prevent degradation.

Appearance

Yellow oval film-coated tablet

Package unit

[For domestic use] 30 tablets/bottle, 500 tablets/bottle [For export] 50 tablets (10 tablets/PTP packaging × 5)