Mephron Tablet (Methylprednisolone)

Adult use

The initial dose may vary from 4mg to 48mg per day as methylprednisolone, depending on the symptoms of the specific disease. In general, a low dose is sufficient for less severe conditions, but a high initial dose may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is achieved. If there is no satisfactory clinical outcome after a reasonable period, treatment should be discontinued and another appropriate treatment initiated. The dose must be determined individually according to the various diseases being treated and the patient's response. After an adequate response is achieved, an appropriate maintenance dose should be determined by reducing the initial dose at suitable intervals until the lowest dose that maintains an adequate clinical response is reached. Continuous monitoring of the dose is required. Situations that may require dose adjustment include remission or worsening of the disease, an individual's response to the medication, and the effect on the patient of exposure to stressful circumstances that are not directly related to the symptoms of the disease being treated. In the latter case, it may be necessary to increase the dose for a period sufficient to achieve a satisfactory response in the patient's condition. After long-term treatment, gradual dose reduction is recommended when discontinuing the medication. For treatment of acute exacerbations of multiple sclerosis, daily administration of prednisolone 200mg for 1 week followed by prednisolone 80mg every other day for 1 month is effective (methylprednisolone 4mg is equivalent to prednisolone 5mg). Alternate-day therapy is a regimen in which twice the daily dose is administered on one morning every 2 days.

This drug should not be used in certain patients. For example, patients who are allergic to this drug or its components, or have had previous experiences of such allergies, should not be administered this medication. Additionally, it is not used in patients with infections where appropriate antibiotics are not available or in patients with systemic fungal infections, as this drug may suppress immune function, worsening the infection. It may also pose risks to patients with herpes simplex, herpes zoster, chickenpox, or those receiving live vaccines or attenuated live vaccines. This medication should be administered with caution in the following patients: Patients with glaucoma may experience increased intraocular pressure, worsening their condition. Patients with tuberculosis or herpetic keratitis may have symptoms that worsen due to immune suppression. Patients with posterior capsule cataracts may experience exacerbated symptoms due to lens effects. Electrolyte imbalance or hypertension patients may see worsened symptoms due to electrolyte metabolism changes. Those with thromboembolism may have worsened conditions due to enhanced blood clotting. Recently operated patients with intestinal anastomosis may have delayed wound healing. Caution is also warranted for patients with a history of acute myocardial infarction due to the risk of cardiac rupture. Patients with diverticulitis, peptic ulcers, severe psychiatric disorders, and osteoporosis may also experience worsening symptoms when using this drug. Patients with infections or diabetes, renal failure or congestive heart failure, and those with hypothyroidism require careful administration. Furthermore, patients with fatty liver, fat embolism, severe myasthenia gravis, the elderly, epileptic patients, and those with ulcerative colitis may be affected by this drug. When using this medication, it is important to closely monitor as various side effects may arise. Fluid or electrolyte imbalances may lead to edema, hypertension, and heart failure. Muscle or bone-related issues may cause muscle weakness, osteoporosis, fractures, etc. Gastrointestinal symptoms may include nausea, vomiting, changes in appetite, peptic ulcers, and pancreatitis. Skin reactions can include delayed wound healing, rashes, hair loss, and acne. Neuropsychiatric issues may lead to headaches, dizziness, insomnia, and depression. Endocrine system reactions can result in Cushing's syndrome, growth suppression, and worsening diabetes. Ocular complications may include increased intraocular pressure, glaucoma, cataracts, and infections, necessitating regular examinations. Immune system abnormalities and allergic reactions have also been reported. Long-term use of this medication may lead to decreased adrenal function, and sudden cessation may result in severe symptoms, hence, gradual reduction is necessary. There is a decreased resistance to infections, so precautions must be taken to avoid exposure to infectious diseases. Exposure to infectious diseases such as chickenpox or measles can lead to severe consequences, hence vaccination status should be verified, and immediate treatment should be sought if infection occurs. This medication may interact with various drugs, so consultations with a doctor or pharmacist are essential when taking it alongside other medications. Dose adjustments and precautions are particularly necessary when used with heart-related medications, antibiotics, anticoagulants, antidiabetics, and diuretics. During pregnancy, this medication may affect the fetus, and should be used only when absolutely necessary. While breastfeeding, lactation should be discontinued. In pediatric cases, the minimum effective dose should be used, and growth should be monitored closely. In the elderly, due to higher risks of side effects, cautious administration is advised. Lastly, it is crucial to focus on infection prevention during the use of this drug, and any emergence of side effects must be promptly reported to a healthcare professional for appropriate intervention.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, aseptic necrosis of the femoral and humeral epiphysis, steroid myopathy, loss of muscle mass, pathologic fractures of the pelvis, osteoporosis, vertebral compression fractures, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, thirst, vomiting, abdominal pain, anorexia, increased appetite, peptic ulcer, abdominal bloating, pancreatitis, esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechiae, purpura, suppression of skin reactions, purpura, acne, hirsutism, alopecia, pigmentation, nipple edema, increased intracranial pressure, convulsions, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, growth retardation in children, symptoms of latent diabetes mellitus, secondary adrenal insufficiency, pituitary unresponsiveness, decreased glucose tolerance, increased requirement for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, elevated intraocular pressure, glaucoma, posterior capsule cataract, secondary infection of the eye due to fungi or viruses, central serous chorioretinopathy, retinal disorders, exophthalmos, negative nitrogen balance, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. It is recommended to maintain storage temperatures between 1 to 30 degrees Celsius at room temperature. Proper storage helps retain the drug's effectiveness for a longer period.

Appearance

White oval tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 300 tablets/bottle